Krajina: Malajzia
Jazyk: angličtina
Zdroj: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
MONENSIN SODIUM
PAHANG PHARMACY SDN. BHD.
MONENSIN SODIUM
20 kg
Biovet Joint Stock Company
STATEMENT OF THE ACTIVE SUBSTANCE: Monensin sodium 200 g/kg PRODUCT DESCRIPTION: ® Coxidin 200 g/kg MicroGranulate represents granules of beige to brown colour intended for administration through feed of poultry. PHARMACODYNAMICS: Monensin sodium acts as an ionophore, i.e. a chemical substance that complexes monovalent cations with the lipophilic structure that facilitates the transport of the bound ion through biological membranes. Coccidial sporozoites exposed to monensin sodium in the intestinal lumen exhibit considerable swelling, large vacuoles, pitting and holes in the surface suggesting extreme osmotic damage which is potentially lethal. Development of a sporozoite that successfully invades a host cell is inhibited as the ionophore continues its destructive process. Monensin sodium selectively destroys intracellular sporozoites while remaining relatively non-injurious to the host cell. It has been shown that monensin sodium has an effect on second generation merozoites but not upon developing gametocytes. PHARMACOKINETICS: In the chicken monensin sodium is absorbed at a limited extent. It is metabolized extensively and gives rise to demethylated, oxidized and decarboxylated metabolites, found in the excreta and tissues where they represent each less than 10% of the total monensin derivatives. The proportion of unchanged monensin in the excreta measured during a relatively short initial excretion period (8 hrs) is 95% and 63% for the chicken and turkey, respectively. The studies on monensin residues in chicken and turkey show that the highest contents are found in the skin plus fat then the liver for both species and that their remanence is very limited in all tissues (less than 24 hours). Monensin sodium is excreted rapidly mainly through the faeces with considerable biliary excretion. INDICATIONS FOR USE: As an aid in the prevention of coccidiosis caused by _Eimeria acervulina, E. brunetti, E. maxima, E. _ _mivati, _ _E. _ _necatrix _ and _E. _ _tenella_ in poultry (broilers and replacement layers). RECO Prečítajte si celý dokument