BAYTRIL TABLET

国家: 加拿大

语言: 英文

来源: Health Canada

有效成分:

ENROFLOXACIN

可用日期:

ELANCO CANADA LIMITED

剂量:

22.7MG

药物剂型:

TABLET

组成:

ENROFLOXACIN 22.7MG

给药途径:

ORAL

每包单位数:

100/500

处方类型:

Prescription

治疗组:

CATS; DOGS

產品總結:

Active ingredient group (AIG) number: 0121066002

授权状态:

APPROVED

授权日期:

2021-01-06

资料单张

Pr
Baytril 22.7 mg and 68 mg Package Insert
04Jan2021
PR
BAYTRIL
1
22.7 MG AND 68 MG PACKAGE INSERT
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DIN 02169444 - 22.7 mg
3
DIN 02169452 - 68 mg
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_ _
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_PR _BAYTRIL_ _
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(ENROFLOXACIN)
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ANTIMICROBIAL TABLETS
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FOR VETERINARY USE ONLY
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DESCRIPTION: Enrofloxacin is a synthetic chemo-therapeutic agent from
the class of
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the quinolone carboxylic acid derivatives. It has antibacterial
activity against a broad
13
spectrum of Gram negative and Gram positive bacteria. (See Table 1).
It is rapidly
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absorbed from the digestive tract, penetrating into all measured body
tissues and fluids.
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(See Table 2). Tablets are available in three sizes (22.7, 68.0 mg
enrofloxacin).
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CHEMICAL NOMENCLATURE:
1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-
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dihydro-4-oxo-3-quinolinecarboxylic acid.
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ACTIONS:
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MICROBIOLOGY: Enrofloxacin, a 4-fluoroquinolone compound, is
bactericidal with activity
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against a broad spectrum of both Gram negative and Gram positive
bacteria.
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Fluoroquinolones elicit their bactericidal properties through
interactions with two
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intercellular enzymes - DNA gyrase (DNA topoisomerase II) and DNA
topoisomerase
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IV - which are essential for bacterial DNA transcription, synthesis
and replication. It is
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believed that fluoroquinolones actively bind with DNA:ENZYME complexes
and thereby
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inhibit the essential processes catalyzed by the enzymes (DNA
supercoiling and
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chromosomal decatenation)
1
. The ultimate outcome of fluoroquinolone intervention is
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DNA fragmentation and bacterial cell death.
2,3
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Enrofloxacin minimum inhibitory concentrations (MICs) were determined
for canine and
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feline bacterial isolates originating from natural infections of the
dermal, gastrointestinal,
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respiratory and urinary systems. Seven hundred and thirty eight (738)
isolates were
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collected from 14 different diagnostic laboratories located throughout
the United States.
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Bacterial identity was confirmed by colony morphology, Gram stain and
biochemical
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testing; for mycoplas