País: Canadá
Idioma: inglés
Fuente: Health Canada
ENROFLOXACIN
ELANCO CANADA LIMITED
22.7MG
TABLET
ENROFLOXACIN 22.7MG
ORAL
100/500
Prescription
CATS; DOGS
Active ingredient group (AIG) number: 0121066002
APPROVED
2021-01-06
Pr Baytril 22.7 mg and 68 mg Package Insert 04Jan2021 PR BAYTRIL 1 22.7 MG AND 68 MG PACKAGE INSERT 2 DIN 02169444 - 22.7 mg 3 DIN 02169452 - 68 mg 4 _ _ 5 _PR _BAYTRIL_ _ 6 (ENROFLOXACIN) 7 ANTIMICROBIAL TABLETS 8 9 FOR VETERINARY USE ONLY 10 11 DESCRIPTION: Enrofloxacin is a synthetic chemo-therapeutic agent from the class of 12 the quinolone carboxylic acid derivatives. It has antibacterial activity against a broad 13 spectrum of Gram negative and Gram positive bacteria. (See Table 1). It is rapidly 14 absorbed from the digestive tract, penetrating into all measured body tissues and fluids. 15 (See Table 2). Tablets are available in three sizes (22.7, 68.0 mg enrofloxacin). 16 17 CHEMICAL NOMENCLATURE: 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4- 18 dihydro-4-oxo-3-quinolinecarboxylic acid. 19 20 ACTIONS: 21 MICROBIOLOGY: Enrofloxacin, a 4-fluoroquinolone compound, is bactericidal with activity 22 against a broad spectrum of both Gram negative and Gram positive bacteria. 23 Fluoroquinolones elicit their bactericidal properties through interactions with two 24 intercellular enzymes - DNA gyrase (DNA topoisomerase II) and DNA topoisomerase 25 IV - which are essential for bacterial DNA transcription, synthesis and replication. It is 26 believed that fluoroquinolones actively bind with DNA:ENZYME complexes and thereby 27 inhibit the essential processes catalyzed by the enzymes (DNA supercoiling and 28 chromosomal decatenation) 1 . The ultimate outcome of fluoroquinolone intervention is 29 DNA fragmentation and bacterial cell death. 2,3 30 31 Enrofloxacin minimum inhibitory concentrations (MICs) were determined for canine and 32 feline bacterial isolates originating from natural infections of the dermal, gastrointestinal, 33 respiratory and urinary systems. Seven hundred and thirty eight (738) isolates were 34 collected from 14 different diagnostic laboratories located throughout the United States. 35 Bacterial identity was confirmed by colony morphology, Gram stain and biochemical 36 testing; for mycoplas Leer el documento completo