Quốc gia: Malaysia
Ngôn ngữ: Tiếng Anh
Nguồn: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
CARBIMAZOLE
DUOPHARMA (M) SDN. BHD.
CARBIMAZOLE
1000 Tablets; 100 Tablets
DUOPHARMA (M) SDN. BHD.
_ _ 1 THYMAZOLE TABLET Carbimazole (5mg) WHAT IS IN THE LEAFLET 1. What THYMAZOLE is used for 2. How THYMAZOLE works 3. Before you use THYMAZOLE 4. How to use THYMAZOLE 5. While you are using it 6. Side effects 7. Storage and Disposal of THYMAZOLE 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of Revision WHAT THYMAZOLE IS USED FOR THYMAZOLE is used to treat hyperthyroidism or overactive thyroid gland (a condition where the thyroid gland produces too much thyroid hormones). HOW THYMAZOLE WORKS THYMAZOLE belongs to a group of medicines called antihyperthyroidism agents. These medicines work by reducing the production of thyroid hormones. BEFORE YOU USE THYMAZOLE - _When you must not take it _ Do not take THYMAZOLE if: You have had an allergic reaction to THYMAZOLE or any ingredients listed at the end of this leaflet You have a previous history of serious adverse reactions to carbimazole You have obstruction of the windpipe (worsened by enlargement of the thyroid gland) You had inflammation of the pancreas (acute pancreatitis) after administration of carbimazole or thiamazole in the past You are breast-feeding or plan to breast-feed. THYMAZOLE passes into breast milk. Your doctor will discuss the risks and benefits of using THYMAZOLE if you are breast-feeding. - _Before you start to use it _ Tell your doctor if: You are pregnant or plan to become pregnant THYMAZOLE is not generally recommended for use in pregnant women unless the benefits of treatment outweigh the risk of the unborn baby carbimazole may be given during pregnancy but the smallest effective dose should be used and treatment should be discontinued three or four weeks before delivery. You have low white blood cells which usually occur during the first month. You are currently being given a course of iodine as part of your treatment You are allergic to any other medicines, foods, dyes or preservatives THYMAZOLE can cause harm to an unborn baby. If you can get pregnant , use reliabl Đọc toàn bộ tài liệu
[DUOPHARMA (M) SDN BHD] [Page 1/2] [Revision Date: 10.12.2019] THYMAZOLE DESCRIPTION: 7mm round tablet, white in colour with "_Star_" marking and "_DUO 861_". COMPOSITION: Each tablet contains Carbimazole 5 mg. PHARMACODYNAMICS: The normal function of the thyroid gland is to produce thyroid hormones, the chief being L-thyroxine (T4), which is an amino-acid containing 4 atoms of iodine in each molecule. Its formation and release into the circulation are under the control of the pituitary thyrotrophic hormone (T.S.H.). Iodides in the normal diet are absorbed from the gastrointestinal tract, enter the blood stream and are trapped by the thyroid gland. No other tissue in the body has this property. The thyroid is capable of trapping 100 times the amount of iodide that would be expected to enter the gland by normal diffusion. In thyrotoxicosis the gland may collect up to 500 times the normal amount of iodide. Once the iodide is in the gland it is oxidised into iodine by an iodide peroxidase. As has been mentioned earlier, the level of production and release of thyroid hormones is regulated by the thyroid-stimulating hormone of the pituitary. In addition, to some extent thyroid activity is influenced by the level of blood iodide, the temperature of the blood and, to a very much lesser extent, by the nervous system. The thyroid can conserve iodine, and has the ability to liberate iodine for new synthesis from spare iodine-containing molecules. Unlike other hormones, thyroxine acts upon every tissue in the body and is not merely specific for certain organs. The concentration of it that reaches any cell in the body controls the speed with which that cell metabolises. Thyroxine is relatively slow- acting and may take several days to exert its effect but T3 takes only a few hours to alter cell metabolism. Carbimazole is believed to exert its antithyroid effect inhibiting the iodinasation of thyrosine. It is also thought to have some action on the enzyme peroxidase which is required as a catalyst in the synthesis of thyroxin Đọc toàn bộ tài liệu