THYMAZOLE TABLET

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

CARBIMAZOLE

Boleh didapati daripada:

DUOPHARMA (M) SDN. BHD.

INN (Nama Antarabangsa):

CARBIMAZOLE

Unit dalam pakej:

1000 Tablets; 100 Tablets

Dikeluarkan oleh:

DUOPHARMA (M) SDN. BHD.

Risalah maklumat

_ _
1
THYMAZOLE TABLET
Carbimazole (5mg)
WHAT IS IN THE LEAFLET
1.
What
THYMAZOLE
is
used for
2.
How THYMAZOLE works
3.
Before
you
use
THYMAZOLE
4.
How to use THYMAZOLE
5.
While you are using it
6.
Side effects
7.
Storage
and
Disposal
of
THYMAZOLE
8.
Product Description
9.
Manufacturer
and
Product
Registration Holder
10.
Date of Revision
WHAT THYMAZOLE IS USED
FOR
THYMAZOLE is used to treat
hyperthyroidism or overactive
thyroid
gland
(a
condition
where
the
thyroid
gland
produces
too
much
thyroid
hormones).
HOW THYMAZOLE WORKS
THYMAZOLE
belongs
to
a
group
of
medicines
called
antihyperthyroidism
agents.
These
medicines
work
by
reducing
the
production
of
thyroid hormones.
BEFORE
YOU
USE
THYMAZOLE
-
_When you must not take it _
Do not take THYMAZOLE if:

You have
had an allergic
reaction to THYMAZOLE
or any ingredients listed at
the end of this leaflet

You
have
a
previous
history
of
serious
adverse
reactions to carbimazole

You have obstruction of the
windpipe
(worsened
by
enlargement of the thyroid
gland)

You
had
inflammation
of
the
pancreas
(acute
pancreatitis)
after
administration
of
carbimazole
or
thiamazole
in the past

You
are
breast-feeding
or
plan
to
breast-feed.
THYMAZOLE passes into
breast
milk.
Your
doctor
will discuss the risks and
benefits
of
using
THYMAZOLE
if
you
are
breast-feeding.
-
_Before you start to use it _
Tell your doctor if:

You are pregnant or plan to
become
pregnant
THYMAZOLE
is
not
generally recommended for
use
in
pregnant
women
unless
the
benefits
of
treatment outweigh the risk
of
the
unborn
baby
carbimazole may be given
during
pregnancy
but
the
smallest
effective
dose
should
be
used
and
treatment
should
be
discontinued three or four
weeks before delivery.

You have low white blood
cells
which
usually
occur
during the first month.

You
are
currently
being
given a course of iodine as
part of your treatment

You
are
allergic
to
any
other
medicines,
foods,
dyes or preservatives

THYMAZOLE
can
cause
harm to an unborn baby. If
you can get pregnant , use
reliabl

Ciri produk

[DUOPHARMA (M) SDN BHD]
[Page 1/2]
[Revision Date: 10.12.2019]
THYMAZOLE
DESCRIPTION: 7mm round tablet, white in colour with "_Star_" marking
and "_DUO 861_".
COMPOSITION: Each tablet contains Carbimazole 5 mg.
PHARMACODYNAMICS:
The normal function of the thyroid gland is to produce thyroid
hormones, the chief being L-thyroxine (T4), which is an amino-acid
containing 4 atoms of iodine in
each molecule. Its formation and release into the circulation are
under the control of the pituitary thyrotrophic hormone (T.S.H.).
Iodides in the normal diet are absorbed from the
gastrointestinal tract, enter the blood stream and are trapped by the
thyroid gland. No other tissue in the body has this property. The
thyroid is capable of trapping 100 times the amount of
iodide that would be expected to enter the gland by normal diffusion.
In thyrotoxicosis the gland may collect up to 500 times the normal
amount of iodide. Once the iodide is in the gland it is
oxidised into iodine by an iodide peroxidase. As has been mentioned
earlier, the level of production and release of thyroid hormones is
regulated by the thyroid-stimulating hormone of the
pituitary. In addition, to some extent thyroid activity is influenced
by the level of blood iodide, the temperature of the blood and, to a
very much lesser extent, by the nervous system. The
thyroid can conserve iodine, and has the ability to liberate iodine
for new synthesis from spare iodine-containing molecules. Unlike other
hormones, thyroxine acts upon every tissue in the
body and is not merely specific for certain organs. The concentration
of it that reaches any cell in the body controls the speed with which
that cell metabolises. Thyroxine is relatively slow-
acting and may take several days to exert its effect but T3 takes only
a few hours to alter cell metabolism. Carbimazole is believed to exert
its antithyroid effect inhibiting the iodinasation of
thyrosine. It is also thought to have some action on the enzyme
peroxidase which is required as a catalyst in the synthesis of
thyroxin