Quốc gia: Israel
Ngôn ngữ: Tiếng Anh
Nguồn: Ministry of Health
CODEINE AS HEMIHYDRATE; IBUPROFEN
RECKITT BENCKISER (NEAR EAST) LTD
M01AE51
TABLETS
IBUPROFEN 200 MG; CODEINE AS HEMIHYDRATE 10 MG
PER OS
Not required
RECKITT BENCKISER HEALTHCARE INTERNATIONAL LTD, UK
IBUPROFEN, COMBINATIONS
IBUPROFEN, COMBINATIONS
For short term use for the relief of acute (short lasting) moderate pain, such as rheumatic pain (arthritis), muscular pain, backaches, neuralgia, migraine, headache, dental pain and menstrual pain.
2015-01-31
NUROFEN PLUS Tab 25. 12. 2005, RH " ע עבקנ הז ןולע טמרופ " רשואו קדבנ ונכותו תואירבה דרשמ י ." “This leaflet format has been determined by the Ministry of Health and the content thereof has been checked and approved.” NUROFEN ® PLUS TABLETS COMPOSITION Each tablet contains: _Active Ingredient _ Ibuprofen 200 mg Codeine phosphate hemihydrate 12.8 mg (equivalent to codeine 10 mg) _Other Ingredients _ Cellulose, microcrystalline, sodium starch glycollate ( _from potato starch_ ), starch pregelatinised ( _from maize, potato, or rice starch_ ), hypromellose (hydroxypropylmethyl cellulose), titanium dioxide (E 171), talc PHARMACOLOGICAL PARTICULARS _Pharmacodynamic Properties _ Ibuprofen is an analgesic which acts peripherally, inhibiting prostaglandin synthesis and the action of chemical mediators of pain. Codeine is a narcotic analgesic acting on central opiate receptors, although its pharmacological effects are thought to be due largely to its biotransformation to morphine. The combination of a well tolerated peripheral analgesic with a centrally acting analgesic provides optimum pain relief with a lower potential for producing side- effects. _Pharmacokinetic Properties _ The elimination half-life of both ibuprofen and codeine is approximately three hours, and both drugs are given three to fours times daily. The combination of the two drugs is therefore appropriate from a pharmacokinetic viewpoint; the tablet exhibits normal release characteristics for both active substances. INDICATIONS For the relief of pain in such conditions as: rheumatic and muscular pain, backache, neuralgia, migraine, headache, dental pain, dysmenorrhoea, feverishness, symptoms of colds and influenza. CONTRAINDICATIONS Known hypersensitivity to the drug or to any ingredient of the preparation. Patients with a history of, or existing peptic ulceration. Patients with severe hepatic failure, severe renal failure, severe heart failure. Previous allergic reaction to any other pain reliever / fever re Đọc toàn bộ tài liệu