Quốc gia: Hoa Kỳ
Ngôn ngữ: Tiếng Anh
Nguồn: NLM (National Library of Medicine)
Isoflurane (UNII: CYS9AKD70P) (Isoflurane - UNII:CYS9AKD70P)
Dechra Veterinary Products LLC
RESPIRATORY (INHALATION)
PRESCRIPTION
Isospire is used for induction and maintenance of general anesthesia in horses and dogs. Isospire is contraindicated in horses and dogs with known sensitivity to isoflurane or to other halogenated agents.
Isospire is packaged in 250 mL amber-colored bottles. Storage: Store at room temperature 15° to 30°C (59° to 86° F). Approved by FDA under ANADA # 200-129
Abbreviated New Animal Drug Application
ISOSPIRE- ISOFLURANE LIQUID DECHRA VETERINARY PRODUCTS LLC ---------- ISOSPIRE™ (ISOFLURANE) INHALATION ANESTHETIC FOR USE IN HORSES AND DOGS WARNING: Not for use in horses intended for human consumption. CAUTION Federal law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION Isospire is a nonflammable, nonexplosive general inhalation anesthetic agent. Its chemical name is 1-chloro-2,2,2- trifluoroethyl difluoromethyl ether, and its structural formula is: * Each mL contains 99.9% isoflurane. Some physical constants are: Molecular weight 184.5 Boiling point at 760 mm Hg 48.5°C Refractive index n 1.2990-1.3005 Specific gravity 25°/25°C 1.496 Vapor pressure in mm Hg 20°C 238 25°C 295 30°C 367 35°C 450 log P = A + B T where:A = 8.056 B = -1664.58 T = °C + 273.16 Partition coefficients at 37°C: Water/gas 0.61 Equation for vapor pressure calculation: 20 D * 10 vap Blood/gas 1.43 Oil/gas 90.8 Partition coefficients at 25°C - rubber and plastic: Conductive rubber/gas 62.0 Butyl rubber/gas 75.0 Polyvinyl chloride/gas 110.0 Polyethylene/gas ~2.0 Polyurethane/gas ~1.4 Polyolefin/gas ~1.1 Butyl acetate/gas ~2.5 Purity by gas chromatography >99.9% Lower limit of flammability in oxygen or nitrous oxide at 9 joules/sec. and 23°C None Lower limit of flammability in oxygen or nitrous oxide at 900 joules/sec.and 23°C Greater than useful concentration in anesthesia MAC (Minimum Alveolar Concentration) is 1.31% in horses and 1.28% in dogs . Isoflurane is a clear, colorless, stable liquid containing no additives or chemical stabilizers. Isoflurane has a mildly pungent, musty, ethereal odor. Samples stored in indirect sunlight in clear, colorless glass for five years, as well as samples directly exposed for 30 hours to a 2 amp, 115 volt, 60 cycle long wave U.V. light were unchanged in composition as determined by gas chromatography. Isoflurane in one normal sodium methoxide-methanol solution, a strong base, for over six months consumed essentially no alkali, indicative of strong base sta Đọc toàn bộ tài liệu