ISOSPIRE- isoflurane liquid

Ülke: ABD

Dil: İngilizce

Kaynak: NLM (National Library of Medicine)

Aktif bileşen:

Isoflurane (UNII: CYS9AKD70P) (Isoflurane - UNII:CYS9AKD70P)

Mevcut itibaren:

Dechra Veterinary Products LLC

Uygulama yolu:

RESPIRATORY (INHALATION)

Reçete türü:

PRESCRIPTION

Terapötik endikasyonlar:

Isospire is used for induction and maintenance of general anesthesia in horses and dogs. Isospire is contraindicated in horses and dogs with known sensitivity to isoflurane or to other halogenated agents.

Ürün özeti:

Isospire is packaged in 250 mL amber-colored bottles. Storage: Store at room temperature 15° to 30°C (59° to 86° F). Approved by FDA under ANADA # 200-129

Yetkilendirme durumu:

Abbreviated New Animal Drug Application

Ürün özellikleri

ISOSPIRE- ISOFLURANE LIQUID
DECHRA VETERINARY PRODUCTS LLC
----------
ISOSPIRE™
(ISOFLURANE)
INHALATION ANESTHETIC
FOR USE IN HORSES AND DOGS
WARNING: Not for use in horses intended for human consumption.
CAUTION
Federal law restricts this drug to use by or on the order of a
licensed veterinarian.
DESCRIPTION
Isospire is a nonflammable, nonexplosive general inhalation anesthetic
agent. Its
chemical name is 1-chloro-2,2,2- trifluoroethyl difluoromethyl ether,
and its structural
formula is:
*
Each mL contains 99.9% isoflurane.
Some physical constants are:
Molecular weight
184.5
Boiling point at 760 mm Hg
48.5°C
Refractive index n
1.2990-1.3005
Specific gravity
25°/25°C
1.496
Vapor pressure in mm
Hg
20°C
238
25°C
295
30°C
367
35°C
450
log
P
=
A + B
T
where:A = 8.056
B = -1664.58
T = °C + 273.16
Partition coefficients at 37°C:
Water/gas
0.61
Equation for vapor pressure calculation:
20
D
*
10 vap
Blood/gas
1.43
Oil/gas
90.8
Partition coefficients at 25°C - rubber and plastic:
Conductive rubber/gas
62.0
Butyl rubber/gas
75.0
Polyvinyl chloride/gas
110.0
Polyethylene/gas
~2.0
Polyurethane/gas
~1.4
Polyolefin/gas
~1.1
Butyl acetate/gas
~2.5
Purity by gas
chromatography
>99.9%
Lower limit of flammability in
oxygen or nitrous oxide at 9
joules/sec. and 23°C
None
Lower limit of flammability in
oxygen or nitrous oxide at
900 joules/sec.and 23°C
Greater than useful
concentration in anesthesia
MAC (Minimum Alveolar Concentration) is 1.31% in horses and 1.28% in
dogs .
Isoflurane is a clear, colorless, stable liquid containing no
additives or chemical
stabilizers. Isoflurane has a mildly pungent, musty, ethereal odor.
Samples stored in
indirect sunlight in clear, colorless glass for five years, as well as
samples directly
exposed for 30 hours to a 2 amp, 115 volt, 60 cycle long wave U.V.
light were
unchanged in composition as determined by gas chromatography.
Isoflurane in one
normal sodium methoxide-methanol solution, a strong base, for over six
months
consumed essentially no alkali, indicative of strong base sta