Quốc gia: Hoa Kỳ
Ngôn ngữ: Tiếng Anh
Nguồn: NLM (National Library of Medicine)
SODIUM SELENITE (UNII: HIW548RQ3W) (SELENITE ION - UNII:KXO0259XJ1), .ALPHA.-TOCOPHEROL ACETATE, D- (UNII: A7E6112E4N) (.ALPHA.-TOCOPHEROL, D- - UNII:N9PR3490H9)
Merck Sharp & Dohme Corp.
SUBCUTANEOUS
PRESCRIPTION
FOR VETERINARY USE ONLY INDICATIONS BO-SE (selenium, vitamin E) is recommended for the prevention and treatment of white muscle disease (Selenium-Tocopherol Deficiency) syndrome in calves, lambs, and ewes. Clinical signs are: stiffness and lameness, diarrhea and unthriftiness, pulmonary distress and/or cardiac arrest. In sows and weanling pigs, as an aid in the prevention and treatment of diseases associated with Selenium-Toco pherol deficiency, such as hepatic necrosis, mulberry heart disease, and white muscle disease. Where known deficiencies of selenium and/or vitamin E exist, it is advisable, from the prevention and control standpoint, to inject the sow during the last week of pregnancy. CONTRAINDICATIONS DO NOT USE IN PREGNANT EWES. Deaths and abortions have been reported in pregnant ewes injected with this product.
HOW SUPPLIED 100 mL sterile, multiple dose vial, NDC 0061-0807-05.
New Animal Drug Application
BO-SE- SODIUM SELENITE AND .ALPHA.-TOCOPHEROL ACETATE, D- INJECTION, SOLUTION MERCK SHARP & DOHME CORP. ---------- BO-SE (SELENIUM, VITAMIN E) INJECTION FOR VETERINARY USE ONLY PRODUCT INFORMATION CAUTION Federal law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION BO-SE (selenium, vitamin E) is an emulsion of selenium-tocopherol for the prevention and treatment of white muscle disease (Selenium-Tocopherol Deficiency) syndrome in calves, lambs, and ewes, and as an aid in the prevention and treatment of Selenium-Tocopherol Deficiency in sows and weanling pigs. EACH ML CONTAINS: 2.19 mg sodium selenite (equivalent to 1 mg selenium), 50 mg (68 USP units) vitamin E (as _d_- alpha tocopheryl acetate), 250 mg polysorbate 80, 2% benzyl alcohol (preservative), water for injection q.s. Sodium hydroxide and/or hydrochloric acid may be added to adjust pH. PHARMACOLOGY It has been demonstrated that selenium and tocopherol exert physiological effects and that these effects are intertwined with sulfur metabolism. Additionally, tocopherol appears to have a significant role in the oxidation process, thus suggesting an interrelationship between selenium and tocopherol in overcoming sulfur induced depletion and restoring normal metabolism. Although oral ingestion of adequate amounts of selenium and tocopherol would seemingly restore normal metabolism, it is apparent that the presence of sulfur and, perhaps, other factors interfere during the digestive processwith proper utilization of selenium and tocopherol. When selenium and tocopherol are injected, they bypass the digestive process and exert their full metabolic effects promptly on cell metabolism. Anti-inflammatory action has been demonstrated by selenium-tocopherol in the Selye Pouch Technique and experimentally induced polyarthritis study in rats. INDICATIONS BO-SE (selenium, vitamin E) is recommended for the prevention and treatment of white muscle disease (Selenium-Tocopherol Deficiency) syndrome in calves, lambs, and ewes. Clinical sig Đọc toàn bộ tài liệu