BO-SE- sodium selenite and .alpha.-tocopherol acetate, d- injection, solution

Χώρα: Ηνωμένες Πολιτείες

Γλώσσα: Αγγλικά

Πηγή: NLM (National Library of Medicine)

Δραστική ουσία:

SODIUM SELENITE (UNII: HIW548RQ3W) (SELENITE ION - UNII:KXO0259XJ1), .ALPHA.-TOCOPHEROL ACETATE, D- (UNII: A7E6112E4N) (.ALPHA.-TOCOPHEROL, D- - UNII:N9PR3490H9)

Διαθέσιμο από:

Merck Sharp & Dohme Corp.

Οδός χορήγησης:

SUBCUTANEOUS

Τρόπος διάθεσης:

PRESCRIPTION

Θεραπευτικές ενδείξεις:

FOR VETERINARY USE ONLY INDICATIONS BO-SE (selenium, vitamin E) is recommended for the prevention and treatment of white muscle disease (Selenium-Tocopherol Deficiency) syndrome in calves, lambs, and ewes. Clinical signs are: stiffness and lameness, diarrhea and unthriftiness, pulmonary distress and/or cardiac arrest. In sows and weanling pigs, as an aid in the prevention and treatment of diseases associated with Selenium-Toco pherol deficiency, such as hepatic necrosis, mulberry heart disease, and white muscle disease. Where known deficiencies of selenium and/or vitamin E exist, it is advisable, from the prevention and control standpoint, to inject the sow during the last week of pregnancy. CONTRAINDICATIONS DO NOT USE IN PREGNANT EWES. Deaths and abortions have been reported in pregnant ewes injected with this product.

Περίληψη προϊόντος:

HOW SUPPLIED 100 mL sterile, multiple dose vial, NDC 0061-0807-05.

Καθεστώς αδειοδότησης:

New Animal Drug Application

Αρχείο Π.Χ.Π.

BO-SE- SODIUM SELENITE AND .ALPHA.-TOCOPHEROL ACETATE, D- INJECTION,
SOLUTION
MERCK SHARP & DOHME CORP.
----------
BO-SE
(SELENIUM, VITAMIN E)
INJECTION
FOR VETERINARY USE ONLY
PRODUCT
INFORMATION
CAUTION Federal law restricts this drug to use by or on the order of a
licensed
veterinarian.
DESCRIPTION BO-SE (selenium, vitamin E) is an emulsion of
selenium-tocopherol for
the prevention and treatment of white muscle disease
(Selenium-Tocopherol Deficiency)
syndrome in calves, lambs, and ewes, and as an aid in the prevention
and treatment of
Selenium-Tocopherol Deficiency in sows and weanling pigs. EACH ML
CONTAINS: 2.19
mg sodium selenite (equivalent to 1 mg selenium), 50 mg (68 USP units)
vitamin E (as _d_-
alpha tocopheryl acetate), 250 mg polysorbate 80, 2% benzyl alcohol
(preservative),
water for injection q.s. Sodium hydroxide and/or hydrochloric acid may
be added to
adjust pH.
PHARMACOLOGY It has been demonstrated that selenium and tocopherol
exert
physiological effects and that these effects are intertwined with
sulfur metabolism.
Additionally, tocopherol appears to have a significant role in the
oxidation process, thus
suggesting an interrelationship between selenium and tocopherol in
overcoming sulfur
induced depletion and restoring normal metabolism. Although oral
ingestion of adequate
amounts of selenium and tocopherol would seemingly restore normal
metabolism, it is
apparent that the presence of sulfur and, perhaps, other factors
interfere during the
digestive processwith proper utilization of selenium and tocopherol.
When selenium and
tocopherol are injected, they bypass the digestive process and exert
their full metabolic
effects promptly on cell metabolism. Anti-inflammatory action has been
demonstrated
by selenium-tocopherol in the Selye Pouch Technique and experimentally
induced
polyarthritis study in rats.
INDICATIONS BO-SE (selenium, vitamin E) is recommended for the
prevention and
treatment of white muscle disease (Selenium-Tocopherol Deficiency)
syndrome in calves,
lambs, and ewes. Clinical sig