Quốc gia: Malaysia
Ngôn ngữ: Tiếng Anh
Nguồn: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
Paracetamol
ABIOTIDE SDN. BHD.
Paracetamol
120 ml
HOVID BERHAD
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _ AETOS PARACETAMOL 250MG/5ML SUSPENSION Paracetamol (250 mg in 5 ml) 1 WHAT IS IN THIS LEAFLET 1. What Aetos Paracetamol Suspension is used for 2. How Aetos Paracetamol Suspension works 3. Before you use Aetos Paracetamol Suspension 4. How to use Aetos Paracetamol Suspension 5. While you are using Paracetamol Suspension 6. Side effects 7. Storage and Disposal of Paracetamol Suspension 8. Product description 9. Manufacturer and Product Registration Holder 10. Date of revision WHAT AETOS PARACETAMOL SUSPENSION IS USED FOR Aetos Paracetamol Suspension is used to relief fever, headache and symptoms of colds and flu, toothache, discomfort of teething and fever after vaccination. HOW AETOS PARACETAMOL SUSPENSION WORKS Aetos Paracetamol Suspension contains Paracetamol that helps to block pain stimulation and it acts on heat- regulating center in brain. This results in increase in blood flow through skin, sweating and heat loss. BEFORE YOU USE AETOS PARACETAMOL SUSPENSION _ _ _- When you must not use it _ Do not take this medicine if: • You have ever had an allergic reaction to paracetamol. • You have severe and active liver impairment. This preparation contains PARACETAMOL. Do not take any other paracetamol containing medicines at the same time. If you are not sure whether you should start taking this medicine, talk to your pharmacist or doctor. _- Before you start to use it _ Tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription, as they may interact with Aetos Paracetamol Suspension. Allergy alert: Paracetamol may cause severe skin reactions. Symptoms may include skin reddening, blisters or rash. These could be signs of a serious condition. If these reactions occur, stop use and seek medical assistance right away. _ _ _- Taking other medicines_ The use of anti-psychotic medicines such as barbiturate, tricyclic antidepressants and alcohol may increase liver toxicity of the paracetamol. Medi Đọc toàn bộ tài liệu
DESCRIPTION Pink, viscous suspension with raspberry flavour. COMPOSITION Each 5 ml contains: Paracetamol 250 mg PHARMACODYNAMICS Paracetamol is a centrally acting analgesic and antipyretic with minimal anti-inflammatory properties. ANALGESIC: The mechanism of analgesic action has not been fully determined. Paracetamol may act predominantly by inhibiting prostaglandin synthesis in the central nervous system (specifically cyclooxygenase (COX)-2) and, to a lesser extent, through a peripheral action by blocking pain-impulse generation. The peripheral action may also be due to inhibition of prostaglandin synthesis or to inhibition of the synthesis or actions of other substances that sensitize pain receptors to mechanical or chemical stimulation. ANTIPYRETIC: Paracetamol act centrally on the hypothalamic heat-regulating center to produce peripheral vasodilatation resulting in increase blood flow through the skin, sweating and heat loss. Paracetamol reduces fever by inhibiting the formulation and release of prostaglandins in the CNS and by inhibiting endogenous pyrogens at the hypothalamic thermoregulator center. PHARMACOKINETICS Following oral administration paracetamol is rapidly absorbed. Paracetamol absorption takes place mainly in the small intestine and therefore the rate of absorption is depending on the rate of gastric emptying. It has been shown that drugs which delay gastric emptying also delay the absorption of paracetamol whereas metoclopramide (a drug which increases the rate of gastric emptying) accelerates absorption of the analgesic through the total amount absorbed doses not increase. The presence of food in the stomach has also been reported to reduce the rate of absorption of paracetamol. Alterations in gastric pH have no appreciable effect on paracetamol absorption. During absorption, the amount of paracetamol which is inactivated is negligible and it has been shown that paracetamol does not affect gastric mucosal permeability and does not produce mucosal bleeding. Peak plasma concentrations are reac Đọc toàn bộ tài liệu