Страна: Австралія
мова: англійська
Джерело: Department of Health (Therapeutic Goods Administration)
Pericyazine
NEULACTIL ® _pericyazine_ CONSUMER MEDICINE INFORMATION (CMI) WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Neulactil. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor or pharmacist has weighed the risks of you taking Neulactil against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again. WHAT NEULACTIL IS USED FOR The active ingredient of Neulactil is pericyazine, one of a group of medicines called phenothiazines. Neulactil is used to treat patients who feel very anxious and/or tense. It is used in patients to control symptoms such as impulsiveness and aggression. It is also used in patients with severe mental conditions when a person loses contact with reality and is unable to think and judge clearly. Your doctor may have prescribed Neulactil for another reason. ASK YOUR DOCTOR OR PHARMACIST IF YOU HAVE ANY QUESTIONS ABOUT WHY NEULACTIL HAS BEEN PRESCRIBED FOR YOU. BEFORE YOU TAKE IT _WHEN YOU MUST NOT TAKE IT_ DO NOT TAKE NEULACTIL IF YOU HAVE AN ALLERGY TO NEULACTIL, ANY OTHER DRUGS FROM THE PHENOTHIAZINE FAMILY, AND/OR ANY OF THE INGREDIENTS LISTED AT THE END OF THIS LEAFLET. Symptoms of an allergic reaction may include: • asthma, wheezing or shortness of breath • swelling of the face, lips or tongue which may cause difficulty in swallowing or breathing • hives, itching or skin rash • fainting DO NOT TAKE NEULACTIL IF YOU HAVE ANY OF THE FOLLOWING- • circulatory disorders • blood or bone marrow disorders • a history of high pressure in the eyes (certain types of glaucoma) • if you are receiving local anaesthetics around the spinal cord • uncontrolled fitting disorders • liver problems DO NOT TAKE NEULACTIL AFTER THE EXPIRY DATE (EXP) PRINTED ON THE PACK. If you take this medicine afte Прочитайте повний документ
Neulactil GLUv6 PIv12 13 Sep 11 1 NEULACTIL PRODUCT INFORMATION NAME OF THE MEDICINE Pericyazine DESCRIPTION Pericyazine is 2 -cyano - 10 - 3' - (4 - hydroxpiperidino-propyl) phenothiazine. Pericyazine is a yellow crystalline powder, almost without odour, non-hygroscopic and sensitive to light. It melts at about 115°C. The molecular weight is 365.48. It is insoluble in water, slightly soluble in ether, fairly soluble in ethanol, acetone and benzene and freely soluble in chloroform. PHARMACOLOGY ACTIONS AND PHARMACOKINETICS Pericyazine is a phenothiazine with a piperidine side chain. It has similar antipsychotic action to other phenothiazines but produces more sedation. It also has adrenolytic, anticholinergic and extrapyramidal effects. Pericyazine is well absorbed after oral administration. However, like other phenothiazines, pericyazine appears to be subject to extensive first pass metabolism in the gut and/or liver with low plasma levels of parent compound. A group of 12 healthy human volunteers were administered two 10mg pericyazine capsules. A peak concentration of 150 ng/ml (410 nmol/l) was achieved 2 hours after drug administration and the half-life was approximately 12 hours. In some subjects, detectable amounts of pericyazine were still present in the blood after 36 hours. There is high inter- patient variability. The majority of the product undergoes conjugation in the liver and is excreted in the urine. As with other phenothiazines, high inter-patient variability is to be expected. INDICATIONS Severe anxiety and tension states and the maintenance treatment of the psychotic patient. It is useful in controlling such symptoms as impulsiveness and aggression. CONTRAINDICATIONS Circulatory collapse, acute intoxication with central depression and co Прочитайте повний документ