Neulactil

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Pericyazine

Patient Information leaflet

NEULACTIL
®

_pericyazine_
CONSUMER MEDICINE INFORMATION (CMI)

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Neulactil.
It does not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have risks and
benefits. Your doctor or pharmacist
has weighed the risks of you taking
Neulactil against the benefits they
expect it will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT NEULACTIL IS USED
FOR
The active ingredient of Neulactil is
pericyazine, one of a group of
medicines called phenothiazines.
Neulactil is used to treat patients who
feel very anxious and/or tense.
It is used in patients to control
symptoms such as impulsiveness and
aggression.
It is also used in patients with severe
mental conditions when a person
loses contact with reality and is
unable to think and judge clearly.
Your doctor may have prescribed
Neulactil for another reason.
ASK YOUR DOCTOR OR PHARMACIST IF
YOU HAVE ANY QUESTIONS ABOUT WHY
NEULACTIL HAS BEEN PRESCRIBED FOR
YOU.
BEFORE YOU TAKE IT
_WHEN YOU MUST NOT TAKE IT_
DO NOT TAKE NEULACTIL IF YOU HAVE
AN ALLERGY TO NEULACTIL, ANY OTHER
DRUGS FROM THE PHENOTHIAZINE
FAMILY, AND/OR ANY OF THE
INGREDIENTS LISTED AT THE END OF THIS
LEAFLET.
Symptoms of an allergic reaction
may include:
•
asthma, wheezing or shortness of
breath
•
swelling of the face, lips or
tongue which may cause
difficulty in swallowing or
breathing
•
hives, itching or skin rash
•
fainting
DO NOT TAKE NEULACTIL IF YOU HAVE
ANY OF THE FOLLOWING-
•
circulatory disorders
•
blood or bone marrow disorders
•
a history of high pressure in the
eyes (certain types of glaucoma)
•
if you are receiving local
anaesthetics around the spinal
cord
•
uncontrolled fitting disorders
•
liver problems
DO NOT TAKE NEULACTIL AFTER THE
EXPIRY DATE (EXP) PRINTED ON THE
PACK.
If you take this medicine afte

Summary of Product characteristics

Neulactil GLUv6 PIv12 13 Sep 11 

1 
NEULACTIL  
PRODUCT INFORMATION 
NAME OF THE MEDICINE 
Pericyazine

DESCRIPTION 
Pericyazine
is 2 -cyano - 10 - 3' - (4 - hydroxpiperidino-propyl) phenothiazine. 

Pericyazine is a yellow crystalline
powder, almost without odour, non-hygroscopic and 
sensitive to light.  It melts at about 115°C.  The
molecular weight is 365.48.  It is insoluble in 
water, slightly soluble in ether, fairly soluble in
ethanol, acetone and benzene and freely 
soluble in chloroform.

PHARMACOLOGY 
ACTIONS AND PHARMACOKINETICS 
Pericyazine  is a phenothiazine with a piperidine side chain. 
It has similar antipsychotic 
action to other phenothiazines but produces more
sedation.  It also has adrenolytic, 
anticholinergic and extrapyramidal effects. 

Pericyazine is well absorbed
after oral administration.  However, like other phenothiazines, 
pericyazine appears to be subject to extensive
first pass metabolism in the gut and/or liver 
with low plasma levels of parent compound. 

A group of 12 healthy human volunteers were administered two 10mg pericyazine capsules.  
A peak concentration of 150 ng/ml (410 nmol/l) was achieved 2 hours after drug 
administration and the half-life was approximately 12 hours.  In some subjects, detectable 
amounts of pericyazine were still present in the blood after 36 hours.  There is high inter-
patient variability. 

The majority of the product undergoes conjugation in the
liver and is excreted in the urine. 

As with other phenothiazines, high
inter-patient variability is to be expected. 
INDICATIONS 
Severe anxiety and tension  states and the maintenance
treatment of the psychotic patient.  
It is useful in controlling such symptoms as impulsiveness and
aggression. 
CONTRAINDICATIONS 
Circulatory collapse, acute intoxication with central depression
and co