Страна: Малайзія
мова: англійська
Джерело: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
PROMETHAZINE HYDROCHLORIDE; Carbocisteine
STERILINE SDN. BHD.
PROMETHAZINE HYDROCHLORIDE; Carbocisteine
60ml mL; 90ml mL; 120ml mL
Noripharma Sdn. Bhd.
MUCORID-P SYRUP COMPOSITION: Each 5ml contains Carbocisteine 100mg, Promethazine Hydrochloride 2.5mg and Methylparaben (as preservative) 7.5mg. DESCRIPTION: A brown colored syrup having fruity flavor. PHARMACODYNAMIC: Carbocisteine is a mucolytic agent which decreases the pathological viscosity of the mucus, fluidifies it and facilitates its evacuation, thus promoting recovery. As a mucoregulatory agent, it helps generate the impaired mucosa. Promethazine is a long acting antihistamine with a mild atropine-like anticholinergic effect and because of its marked effect on the central nervous system, is of great value as an antiemetic, hypnotic, tranquilizer, a potentiator of anaesthetic, hypnotics, sedatives and analgesics. PHARMACOKINETIC: Carbocisteine is rapidly and well absorbed from the gastrointestinal tract with peak plasma concentrations occurring 90 to 120 minutes after an oral dose. It appears to penetrate into lung tissue and respiratory mucus. Carbocisteine is excreted in the urine as unchanged drug and metabolites. Acetylation, decarboxylation and sulfoxidation have been identified as the major metabolic pathways. Sulfoxidation may be governed by genetic polymorphism. Promethazine is well absorbed from the gastrointestinal tract. Clinical effects are apparent within 20 minutes after oral administration and generally last four to six hours, although they may persist as long as 12 hours. Promethazine is metabolized by the liver to a variety of compounds; the sulfoxides of promethazine and N-demethylpromethazine are the predominant metabolites appearing in the urine. INDICATION: Symptomatic treatment of troublesome, non-productive cough, particularly occurring at night. RECOMMENDED DOSAGE: For adults and children over the age of 2 years only. Symptomatic treatment should be for a short period (a few days) and restricted when cough occurs. Adults: 3 to 4 tablespoonfuls (15ml) daily. Children: 24 to 30 months: 15 - 20ml per day 30 months to 12 years: 20 - 30ml per day 12 to 15 years: 30 - 45ml per day Becaus Прочитайте повний документ