IDAMAN PHARMA ALBENDAZOLE SUSPENSION 200MG5ML

Страна: Малайзія

мова: англійська

Джерело: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Активний інгредієнт:

ALBENDAZOLE

Доступна з:

IDAMAN PHARMA MANUFACTURING SDN BHD

ІПН (Міжнародна Ім'я):

ALBENDAZOLE

Одиниць в упаковці:

10 ml

Виробник:

IDAMAN PHARMA MANUFACTURING SDN BHD

Характеристики продукта

IDAMAN PHARMA MANUFACTURING
IDAMAN PHARMA ALBENDAZOLE SUSPENSION
200MG/ 5ML
DESCRIPTION
Uniform,
opaque,
mobile,
viscous
liquid
white
to
beige
coloured,
fruit
flavoured
suspension,
free
from
visible
impurities.
Each 5ml of suspension contains Albendazole 200mg
Preservatives:
Methyl Paraben: 10mg
Propyl Paraben : 2.5mg
ROUTE
OF ADMINISTRATION
Oral
PHARMACODYNAMICS
Albendazole is a benzimidazole carbamate anthelmintic drug
similar to mebendazole. It is a broad-spectrum anthelmintic,
which is highly effective against a wide range of intestinal
helminths
including
a
variety
of
intestinal
nematodes,
cestodes, and trematodes. It is also effective against tissue
helminth infections, such as cutaneous larva migrans and has
also been used in the high dose, long term treatment of
tissue
helminth
infections
including
hydatid
cysts
and
cysticercosis.
The antihelminthic action of albendazole is thought to be
mainly intra-intestinal due to low absorption (less than 5%)
after
oral
administration.
However,
at
higher
albendazole
doses, sufficient amount is absorbed and metabolised to the
active sulphoxide metabolite, to have a therapeutic effect
against tissue parasites.
Albendazole
exhibits
larvicidal,
ovicidal
and
vermicidal
activity,
and
is
thought
to
act
via
inhibition
of
tubulin
polymerization.
This
causes
a
cascade
of
metabolic
disruption,
including
energy
depletion,
which
immobilizes
and then kills the susceptible helminth.
PHARMACOKINETICS
ABSORPTION:
In man, the full extent of albendazole absorption following
oral administration has not been established. However, it is
known that albendazole is poorly absorbed (<5%) with most
of an oral dose remaining in the gastrointestinal tract. The
poor absorption is believed to be due to the low aqueous
solubility of albendazole. Absorption is significantly enhanced
(up to 5-fold) if albendazole is administered with a fatty meal
compared with fasted state.
METABOLISM
:
Albendazole
rapidly
undergoes
extensive
first-pass
metabolism in the liver, and is generally not detected in
plasma