Nchi: Malesia
Lugha: Kiingereza
Chanzo: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
ALBENDAZOLE
IDAMAN PHARMA MANUFACTURING SDN BHD
ALBENDAZOLE
10 ml
IDAMAN PHARMA MANUFACTURING SDN BHD
IDAMAN PHARMA MANUFACTURING IDAMAN PHARMA ALBENDAZOLE SUSPENSION 200MG/ 5ML DESCRIPTION Uniform, opaque, mobile, viscous liquid white to beige coloured, fruit flavoured suspension, free from visible impurities. Each 5ml of suspension contains Albendazole 200mg Preservatives: Methyl Paraben: 10mg Propyl Paraben : 2.5mg ROUTE OF ADMINISTRATION Oral PHARMACODYNAMICS Albendazole is a benzimidazole carbamate anthelmintic drug similar to mebendazole. It is a broad-spectrum anthelmintic, which is highly effective against a wide range of intestinal helminths including a variety of intestinal nematodes, cestodes, and trematodes. It is also effective against tissue helminth infections, such as cutaneous larva migrans and has also been used in the high dose, long term treatment of tissue helminth infections including hydatid cysts and cysticercosis. The antihelminthic action of albendazole is thought to be mainly intra-intestinal due to low absorption (less than 5%) after oral administration. However, at higher albendazole doses, sufficient amount is absorbed and metabolised to the active sulphoxide metabolite, to have a therapeutic effect against tissue parasites. Albendazole exhibits larvicidal, ovicidal and vermicidal activity, and is thought to act via inhibition of tubulin polymerization. This causes a cascade of metabolic disruption, including energy depletion, which immobilizes and then kills the susceptible helminth. PHARMACOKINETICS ABSORPTION: In man, the full extent of albendazole absorption following oral administration has not been established. However, it is known that albendazole is poorly absorbed (<5%) with most of an oral dose remaining in the gastrointestinal tract. The poor absorption is believed to be due to the low aqueous solubility of albendazole. Absorption is significantly enhanced (up to 5-fold) if albendazole is administered with a fatty meal compared with fasted state. METABOLISM : Albendazole rapidly undergoes extensive first-pass metabolism in the liver, and is generally not detected in plasma Soma hati kamili