Страна: Малайзія
мова: англійська
Джерело: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
GLIBENCLAMIDE
HOVID BERHAD
GLIBENCLAMIDE
100Tablet Tablets
HOVID BERHAD
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _ CLAMIDE TABLET 5 MG Glibenclamide 5 mg 1 WHAT IS IN THIS LEAFLET 1. What Clamide is used for 2. How Clamide works 3. Before you use Clamide 4. How to use Clamide 5. While you are using Clamide 6. Side effects 7. Storage and Disposal of Clamide 8. Product description 9. Manufacturer and Product Registration Holder 10. Date of revision WHAT CLAMIDE IS USED FOR It is used to treat mild or moderately severe uncomplicated diabetes mellitus, which controlling diet is not workable. HOW CLAMIDE WORKS This medicine belongs to a group known as antidiabetic agent, which act to reduce blood glucose level. It works by promoting release of insulin from pancreas. It also decrease the conversion of food to glucose and increase the sensitivity of other body tissues towards insulin. BEFORE YOU USE CLAMIDE _- When you must not use it _ _ _ Do not take this medicine if: • you are allergic to antidiabetic or any of the ingredients listed at the end of this leaflet. • you have burns, severe infection, congenital diabetes, coma due to diabetes, major surgery, severe trauma. • you have increased ketones level. • you have failure on kidney, liver, thyroid or adrenal glands. • you are pregnant or breastfeeding. If you are not sure whether you should start taking this medicine, talk to your pharmacist or doctor. _- Before you start to use it _ _ _ Tell your doctor/pharmacist if: • you have problems with your kidneys, liver, thyroid or adrenal gland • you are pregnant, think you are pregnant or plan to become pregnant • you are breastfeeding or plan to breastfeed • you suffer from burns, severe infection, congenital diabetes, coma due to diabetes, major surgery, severe trauma. _- Taking other medicines _ _ _ Tell your doctor or pharmacist before taking Clamide if you are taking any other medicines, including any that you buy without a prescription from pharmacy, supermarket or health food shop. The effects of some medicines may be affected if other medicines are used at th Прочитайте повний документ
VICLA18-var (MY) CLAMIDE TABLET DESCRIPTION Oblong, white uncoated tablet, bevel-edged, flat faces, “HD” embossed and scored on the same face COMPOSITION Each tablet contains: Glibenclamide 5 mg PHARMACODYNAMICS Glibenclamide is an oral hypoglycaemia agent with actions similar to those of chlorpropamide. It promotes the increased secretion of insulin from the beta cells of islet tissue in the pancreas by means of a process not yet specifically defined. It also decreases hepatic glycogenolysis and gluconeogenesis. Apparently, glibenclamide increase the insulin sensitivity of extrapancreatic tissues. The overall effect is a reduction in blood glucose concentration only in those patients whose pancreas is capable of synthesizing insulin. Oral antidiabetic medications apparently do not influence the production of insulin by the beta cells but seem to enhance its release from these pancreatic cells. PHARMACOKINETICS ABSORPTION: About 45% of a 5 mg dose is absorbed after oral administration BLOOD CONCENTRATION: After an oral dose of 5 mg, peak serum concentration of about 0.05 ug/ml are attained in 2 to 4 hours. HALF-LIFE: Plasma half-life, 3 to 7 hours; half-life determined from urinary excretion data, about 10 hours. DISTRIBUTION: Widely distributed throughout the body and does not appear to accumulate PROTEIN BINDING: About 98% bound to plasma proteins. METABOLIC REACTIONS: Hydroxylation of the cyclohexyl ring at positions 3 and 4 ; in the rat, rabbit and dog the 3-cis hydroxy metabolite is formed and in the rat the 4-trans-hydroxy metabolite is additionally produced; hydroxylated metabolites may be conjugated EXCRETION: In 5 days, 95% of a dose is excreted in the urine and faeces with about 54% excreted as unchanged drug; of the 95% excreted about 75% is found in the faeces and 20% in the urine; excretion of an intravenous dose is more rapid than that from either oral or intramuscular doses. INDICATIONS For treatment of mild or moderately severe uncomplicated maturity-onset diabetes mellitus unresponsive to die Прочитайте повний документ