CLAMIDE TABLET 5MG

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

GLIBENCLAMIDE

Boleh didapati daripada:

HOVID BERHAD

INN (Nama Antarabangsa):

GLIBENCLAMIDE

Unit dalam pakej:

100Tablet Tablets

Dikeluarkan oleh:

HOVID BERHAD

Risalah maklumat

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
CLAMIDE TABLET 5 MG
Glibenclamide 5 mg
1
WHAT IS IN THIS LEAFLET
1.
What Clamide is used for
2.
How Clamide works
3.
Before you use Clamide
4.
How to use Clamide
5.
While you are using Clamide
6.
Side effects
7.
Storage and Disposal of Clamide
8.
Product description
9.
Manufacturer
and
Product
Registration Holder
10.
Date of revision
WHAT CLAMIDE IS USED FOR
It is used to treat mild or moderately
severe uncomplicated diabetes mellitus,
which controlling diet is not workable.
HOW CLAMIDE WORKS
This
medicine
belongs
to
a
group
known as antidiabetic agent, which act
to reduce blood glucose level. It works
by promoting release of insulin from
pancreas.
It also decrease the conversion of food
to glucose and increase the sensitivity of
other body tissues towards insulin.
BEFORE YOU USE CLAMIDE
_- When you must not use it _
_ _
Do not take this medicine if:
•
you are allergic to antidiabetic or
any of the ingredients listed at the
end of this leaflet.
•
you have burns, severe infection,
congenital
diabetes,
coma
due
to
diabetes,
major
surgery,
severe
trauma.
•
you have increased ketones level.
•
you have failure on kidney, liver,
thyroid or adrenal glands.
•
you are pregnant or breastfeeding.
If you are not sure whether you should
start taking this medicine, talk to your
pharmacist or doctor.
_- Before you start to use it _
_ _
Tell your doctor/pharmacist if:
•
you
have
problems
with
your
kidneys,
liver,
thyroid
or
adrenal
gland
•
you
are
pregnant,
think
you
are
pregnant
or
plan
to
become
pregnant
•
you
are
breastfeeding
or
plan
to
breastfeed
•
you
suffer
from
burns,
severe
infection, congenital diabetes, coma
due
to
diabetes,
major
surgery,
severe trauma.
_- Taking other medicines _
_ _
Tell your doctor or pharmacist before
taking Clamide if you are taking any
other medicines, including any that you
buy
without
a
prescription
from
pharmacy, supermarket or health food
shop.
The
effects
of
some
medicines
may be affected if other medicines are
used at th

Ciri produk

VICLA18-var (MY)
CLAMIDE TABLET
DESCRIPTION
Oblong, white uncoated tablet, bevel-edged, flat faces, “HD”
embossed and scored on the same face
COMPOSITION
Each tablet contains: Glibenclamide 5 mg
PHARMACODYNAMICS
Glibenclamide is an oral hypoglycaemia agent with actions
similar to those of chlorpropamide. It promotes the increased
secretion of insulin from the beta cells of islet tissue in the
pancreas by means of a process not yet specifically defined.
It
also
decreases
hepatic
glycogenolysis
and
gluconeogenesis. Apparently, glibenclamide increase the
insulin sensitivity of extrapancreatic tissues.
The
overall
effect
is
a
reduction
in
blood
glucose
concentration only in those patients whose pancreas is
capable of synthesizing insulin. Oral antidiabetic medications
apparently do not influence the production of insulin by the
beta cells but seem to enhance its release from these
pancreatic cells.
PHARMACOKINETICS
ABSORPTION: About 45% of a 5 mg dose is absorbed after
oral administration
BLOOD CONCENTRATION: After an oral dose of 5 mg, peak serum
concentration of about 0.05 ug/ml are attained in 2 to 4 hours.
HALF-LIFE: Plasma half-life, 3 to 7 hours; half-life determined
from urinary excretion data, about 10 hours.
DISTRIBUTION: Widely distributed throughout the body and
does not appear to accumulate
PROTEIN BINDING: About 98% bound to plasma proteins.
METABOLIC REACTIONS: Hydroxylation of the cyclohexyl ring at
positions 3 and 4 ; in the rat, rabbit and dog the 3-cis
hydroxy
metabolite
is
formed
and
in
the
rat
the
4-trans-hydroxy
metabolite
is
additionally
produced;
hydroxylated metabolites may be conjugated
EXCRETION: In 5 days, 95% of a dose is excreted in the urine
and faeces with about 54% excreted as unchanged drug; of
the 95% excreted about 75% is found in the faeces and 20%
in the urine; excretion of an intravenous dose is more rapid
than that from either oral or intramuscular doses.
INDICATIONS
For treatment of mild or moderately severe uncomplicated
maturity-onset diabetes mellitus unresponsive to die