Terry White Chemists Clopidogrel

Ülke: Avustralya

Dil: İngilizce

Kaynak: Department of Health (Therapeutic Goods Administration)

Aktif bileşen:

Clopidogrel hydrogen sulfate

Mevcut itibaren:

Apotex Pty Ltd

Sınıf:

Medicine Registered

Bilgilendirme broşürü

TERRY WHITE CHEMISTS
CLOPIDOGREL TABLETS

_Contains the active ingredient, clopidogrel_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
READ THIS LEAFLET CAREFULLY BEFORE
TAKING YOUR MEDICINE. ASK YOUR
DOCTOR OR PHARMACIST IF YOU DO NOT
UNDERSTAND ANYTHING OR ARE
WORRIED ABOUT TAKING YOUR
MEDICINE.
This leaflet answers some common
questions about clopidogrel.
It does not contain all the available
information.
It does not take the place of talking to
your doctor or pharmacist.
The information in this leaflet was
last updated on the date listed on the
last page. Some more recent
information on your medicine may
be available. Speak to your
pharmacist or doctor to obtain the
most up-to-date information.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you using this medicine
against the benefits they expect it
will have for you.
KEEP THIS LEAFLET WITH YOUR
MEDICINE.
You may want to read it again.
WHAT CLOPIDOGREL IS
USED FOR
The name of your medicine is Terry
White Chemists Clopidogrel. It
contains the active ingredient,
clopidogrel.
It is used to prevent blood clots
forming in hardened blood vessels (a
process known as atherothrombosis)
which can lead to events such as
stroke, heart attack or death.
_HOW IT WORKS_
Clopidogrel belongs to a group of
medicine called anti-platelet
medicines.
Platelets are very small blood cells
which clump together during blood
clotting. By preventing this
clumping, anti-platelet medicines
reduce the chances of blood clots
forming (a process called
thrombosis).
You may have been prescribed
clopidogrel to help prevent blood
clots forming and to reduce the risk
of stroke, heart attack or death
because:
•
you have previously suffered a
heart attack, stroke or have a
condition known as peripheral
arterial disease (leg pain on
walking or at rest).
Ask your doctor if you have any
questions about why this medicine
has been prescribed for you.
Your doctor may have prescribed
clopidogrel for another reason.
This medicine is available only with
a

Ürün özellikleri

Product Information 
– Australia 

Terry White Chemists Clopidogrel Tablets 
Page 1 
TERRY WHITE CHEMISTS CLOPIDOGREL TABLETS 

NAME OF THE MEDICINE 
Clopidogrel hydrogen sulphate. 

Chemical Name:  
methyl (+)-(S)-
α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c] pyridine-5(4H)-acetate 
sulphate (1:1) 

Structural Formula: 

[http://dmd.aspetjournals.org/content/vol30/issue11/images/large/dd1120906001.jpeg]

Molecular Formula:  
C
16
H
16
ClNO
2
S.H
2
SO
4

Molecular Weight: 
419.9  

CAS Registry Number:  120202-66-6
(clopidogrel hydrogen sulfate) & 113 665-84-2
(clopidogrel base) 

DESCRIPTION 
Clopidogrel hydrogren sulfate is a  white to off-white powder. It is practically  insoluble  in  water at neutral 
pH but freely soluble at pH 1. It is freely soluble in methanol, sparingly soluble in methylene chloride and 
is practically insoluble in ethyl ether.
It has a specific optical rotation of about +56°. 

PHARMACOLOGY 
PHARMACODYNAMICS 
Clopidogrel is a specific and potent inhibitor of platelet aggregation. Platelets have an established role in 
the  pathophysiology  of  atherosclerotic  disease  and  thrombotic  events.  Long  term  use  of  anti-platelet 
drugs  has  shown  consistent  benefit  in  the  prevention  of  ischaemic  stroke,  myocardial  infarction  and 
vascular  death  in  patients  at  increased  risk  of  such  outcomes,  including  those  with  established 
atherosclerosis or a history of atherothrombosis. 

Clopidogrel  selectively  inhibits  the  binding  of  adenosine  diphosphate  (ADP)  to  its  platelet  receptor,  and 
the  subsequent  ADP-mediated  activation  of  the  GPIIb/IIIa  complex,  thereby  inhibiting  platelet 
aggregation.  

Biotransformation  of  clopidogrel  is  necessar