Land: Australien
Sprog: engelsk
Kilde: Department of Health (Therapeutic Goods Administration)
Clopidogrel hydrogen sulfate
Apotex Pty Ltd
Medicine Registered
TERRY WHITE CHEMISTS CLOPIDOGREL TABLETS _Contains the active ingredient, clopidogrel_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET READ THIS LEAFLET CAREFULLY BEFORE TAKING YOUR MEDICINE. ASK YOUR DOCTOR OR PHARMACIST IF YOU DO NOT UNDERSTAND ANYTHING OR ARE WORRIED ABOUT TAKING YOUR MEDICINE. This leaflet answers some common questions about clopidogrel. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. The information in this leaflet was last updated on the date listed on the last page. Some more recent information on your medicine may be available. Speak to your pharmacist or doctor to obtain the most up-to-date information. All medicines have risks and benefits. Your doctor has weighed the risks of you using this medicine against the benefits they expect it will have for you. KEEP THIS LEAFLET WITH YOUR MEDICINE. You may want to read it again. WHAT CLOPIDOGREL IS USED FOR The name of your medicine is Terry White Chemists Clopidogrel. It contains the active ingredient, clopidogrel. It is used to prevent blood clots forming in hardened blood vessels (a process known as atherothrombosis) which can lead to events such as stroke, heart attack or death. _HOW IT WORKS_ Clopidogrel belongs to a group of medicine called anti-platelet medicines. Platelets are very small blood cells which clump together during blood clotting. By preventing this clumping, anti-platelet medicines reduce the chances of blood clots forming (a process called thrombosis). You may have been prescribed clopidogrel to help prevent blood clots forming and to reduce the risk of stroke, heart attack or death because: • you have previously suffered a heart attack, stroke or have a condition known as peripheral arterial disease (leg pain on walking or at rest). Ask your doctor if you have any questions about why this medicine has been prescribed for you. Your doctor may have prescribed clopidogrel for another reason. This medicine is available only with a Læs hele dokumentet
Product Information – Australia Terry White Chemists Clopidogrel Tablets Page 1 TERRY WHITE CHEMISTS CLOPIDOGREL TABLETS NAME OF THE MEDICINE Clopidogrel hydrogen sulphate. Chemical Name: methyl (+)-(S)- α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c] pyridine-5(4H)-acetate sulphate (1:1) Structural Formula: [http://dmd.aspetjournals.org/content/vol30/issue11/images/large/dd1120906001.jpeg] Molecular Formula: C 16 H 16 ClNO 2 S.H 2 SO 4 Molecular Weight: 419.9 CAS Registry Number: 120202-66-6 (clopidogrel hydrogen sulfate) & 113 665-84-2 (clopidogrel base) DESCRIPTION Clopidogrel hydrogren sulfate is a white to off-white powder. It is practically insoluble in water at neutral pH but freely soluble at pH 1. It is freely soluble in methanol, sparingly soluble in methylene chloride and is practically insoluble in ethyl ether. It has a specific optical rotation of about +56°. PHARMACOLOGY PHARMACODYNAMICS Clopidogrel is a specific and potent inhibitor of platelet aggregation. Platelets have an established role in the pathophysiology of atherosclerotic disease and thrombotic events. Long term use of anti-platelet drugs has shown consistent benefit in the prevention of ischaemic stroke, myocardial infarction and vascular death in patients at increased risk of such outcomes, including those with established atherosclerosis or a history of atherothrombosis. Clopidogrel selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor, and the subsequent ADP-mediated activation of the GPIIb/IIIa complex, thereby inhibiting platelet aggregation. Biotransformation of clopidogrel is necessar Læs hele dokumentet