Ülke: ABD
Dil: İngilizce
Kaynak: NLM (National Library of Medicine)
Oxytetracycline Hydrochloride (UNII: 4U7K4N52ZM) (Oxytetracycline - UNII:X20I9EN955, Oxytetracycline - UNII:X20I9EN955)
Pfizer Labs
Oxytetracycline Hydrochloride
CAPSULE
ORAL
PRESCRIPTION DRUG
Oxytetracycline is indicated in infections caused by the following microorganisms: - Rickettsiae (Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox and tick fevers), - Mycoplasma pneumoniae (PPLO, Eaton Agent), - Agents of psittacosis and ornithosis, - Agents of lymphogranuloma venereum and granuloma inguinale, - The spirochetal agent of relapsing fever (Borrelia recurrentis ). The following gram negative microorganisms: - Haemophilus ducreyi (chancroid), - Pasteurella pestis , and Pasteurella tularensis , - Bartonella bacilliformis , - Bacteroides species, - Vibrio comma and Vibrio fetus , - Brucella species (in conjunction with streptomycin). Because many strains of the following groups of microorganisms have been shown to be resistant to tetracyclines, culture and susceptibility testing are recommended. Oxytetracycline is indicated for treatment of infections caused by the following gram-negative microorganisms, when bacteriologic testing indicates appropr
Terramycin (oxytetracycline HCl) Capsules are available as opaque, yellow, hard gelatin capsules which contain oxytetracycline HCl equivalent to 250 mg of oxytetracycline, and glucosamine hydrochloride: bottles of 100 (NDC 0069-0730-66), 500 (NDC 0069-0730-73).
TERRAMYCIN- OXYTETRACYCLINE HYDROCHLORIDE CAPSULE PFIZER LABS ---------- TERRAMYCIN OXYTETRACYCLINE HYDROCHLORIDE CAPSULES DESCRIPTION Oxytetracycline is a product of the metabolism of _Streptomyces rimosus_ and is one of the family of tetracycline antibiotics. A 1 percent solution in water is acidic (pH about 2.5). Its potency is affected in solutions more acid than pH 2 and it is rapidly destroyed by alkali hydroxides. Oxytetracycline diffuses readily through the placenta into the fetal circulation, into the pleural fluid and, under some circumstances, into the cerebrospinal fluid. It appears to be concentrated in the hepatic system and excreted in the bile, so that it appears in the feces, as well as in the urine, in a biologically active form. Inert ingredients in the formulation are: glucosamine hydrochloride; hard gelatin capsules (which may contain Red 3, Yellow 10 and other inert ingredients); magnesium stearate; sodium lauryl sulfate; starch. ACTIONS Oxytetracycline is primarily bacteriostatic and is thought to exert its antimicrobial effect by the inhibition of protein synthesis. Oxytetracycline is active against a wide range of gram-negative and gram-positive organisms. The drugs in the tetracycline class have closely similar antimicrobial spectra, and cross resistance among them is common. Microorganisms may be considered susceptible if the M.I.C. (minimum inhibitory concentration) is not more than 4.0 mcg/ml and intermediate if the M.I.C. is 4.0 to 12.5 mcg/ml. Susceptibility plate testing: A tetracycline disc may be used to determine microbial susceptibility to drugs in the tetracycline class. If the Kirby-Bauer method of disc susceptibility testing is used, a 30 mcg tetracycline disc should give a zone of at least 19 mm when tested against a tetracycline- susceptible bacterial strain. Tetracyclines are readily absorbed and are bound to plasma proteins in varying degree. They are concentrated by the liver in the bile, and excreted in the urine and feces at high concentrations and in a biologically a Belgenin tamamını okuyun