terramycin- Oxytetracycline Hydrochloride capsule

البلد: الولايات المتحدة

اللغة: الإنجليزية

المصدر: NLM (National Library of Medicine)

العنصر النشط:

Oxytetracycline Hydrochloride (UNII: 4U7K4N52ZM) (Oxytetracycline - UNII:X20I9EN955, Oxytetracycline - UNII:X20I9EN955)

متاح من:

Pfizer Labs

INN (الاسم الدولي):

Oxytetracycline Hydrochloride

الشكل الصيدلاني:

CAPSULE

طريقة التعاطي:

ORAL

نوع الوصفة الطبية :

PRESCRIPTION DRUG

الخصائص العلاجية:

Oxytetracycline is indicated in infections caused by the following microorganisms: - Rickettsiae (Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox and tick fevers), - Mycoplasma pneumoniae (PPLO, Eaton Agent), - Agents of psittacosis and ornithosis, - Agents of lymphogranuloma venereum and granuloma inguinale, - The spirochetal agent of relapsing fever (Borrelia recurrentis ). The following gram negative microorganisms: - Haemophilus ducreyi (chancroid), - Pasteurella pestis , and Pasteurella tularensis , - Bartonella bacilliformis , - Bacteroides species, - Vibrio comma and Vibrio fetus , - Brucella species (in conjunction with streptomycin). Because many strains of the following groups of microorganisms have been shown to be resistant to tetracyclines, culture and susceptibility testing are recommended. Oxytetracycline is indicated for treatment of infections caused by the following gram-negative microorganisms, when bacteriologic testing indicates appropr

ملخص المنتج:

Terramycin (oxytetracycline HCl) Capsules are available as opaque, yellow, hard gelatin capsules which contain oxytetracycline HCl equivalent to 250 mg of oxytetracycline, and glucosamine hydrochloride: bottles of 100 (NDC 0069-0730-66), 500 (NDC 0069-0730-73).

خصائص المنتج

TERRAMYCIN- OXYTETRACYCLINE HYDROCHLORIDE CAPSULE
PFIZER LABS
----------
TERRAMYCIN
OXYTETRACYCLINE
HYDROCHLORIDE
CAPSULES
DESCRIPTION
Oxytetracycline is a product of the metabolism of _Streptomyces
rimosus_ and is one of the family of
tetracycline antibiotics. A 1 percent solution in water is acidic (pH
about 2.5). Its potency is affected in
solutions more acid than pH 2 and it is rapidly destroyed by alkali
hydroxides.
Oxytetracycline diffuses readily through the placenta into the fetal
circulation, into the pleural fluid and,
under some circumstances, into the cerebrospinal fluid. It appears to
be concentrated in the hepatic
system and excreted in the bile, so that it appears in the feces, as
well as in the urine, in a biologically
active form.
Inert ingredients in the formulation are: glucosamine hydrochloride;
hard gelatin capsules (which may
contain Red 3, Yellow 10 and other inert ingredients); magnesium
stearate; sodium lauryl sulfate; starch.
ACTIONS
Oxytetracycline is primarily bacteriostatic and is thought to exert
its antimicrobial effect by the
inhibition of protein synthesis. Oxytetracycline is active against a
wide range of gram-negative and
gram-positive organisms.
The drugs in the tetracycline class have closely similar antimicrobial
spectra, and cross resistance
among them is common. Microorganisms may be considered susceptible if
the M.I.C. (minimum
inhibitory concentration) is not more than 4.0 mcg/ml and intermediate
if the M.I.C. is 4.0 to 12.5
mcg/ml.
Susceptibility plate testing: A tetracycline disc may be used to
determine microbial susceptibility to
drugs in the tetracycline class. If the Kirby-Bauer method of disc
susceptibility testing is used, a 30
mcg tetracycline disc should give a zone of at least 19 mm when tested
against a tetracycline-
susceptible bacterial strain.
Tetracyclines are readily absorbed and are bound to plasma proteins in
varying degree. They are
concentrated by the liver in the bile, and excreted in the urine and
feces at high concentrations and in a
biologically a