Octreotide Sun
Ülke: Avustralya
Dil: İngilizce
Kaynak: Department of Health (Therapeutic Goods Administration)
Bilgilendirme broşürü
(PIL)
17-05-2024
Ürün özellikleri
(SPC)
17-05-2024
Aktif bileşen:
Octreotide
Mevcut itibaren:
Sun Pharmaceuticals Industries Australia Pty Ltd
Sınıf:
Medicine Registered
Bilgilendirme broşürü
Octreotide SUN_CMI_20120203
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OCTREOTIDE SUN
_Octreotide _
_ _
WHAT IS IN THIS LEAFLET
This leaflet answers some common questions about Octreotide SUN.
The information in
this leaflet was last updated on the date listed
on the final page. More recent information
on the medicine may be available.
YOU SHOULD ENSURE THAT YOU SPEAK TO
YOUR PHARMACIST OR DOCTOR TO OBTAIN THE MOST
UP TO DATE INFORMATION ON THE MEDICINE.
Those updates may contain important information
about the medicine and its use of
which you should be aware. It does not contain
all the available information. It does not
take the place of talking to your doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed the risks of you
using Octreotide SUN against the
benefits they expect it will have for you.
IF YOU HAVE ANY CONCERNS ABOUT USING THIS MEDICINE,
ASK YOUR DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT OCTREOTIDE SUN IS USED FOR
Octreotide SUN has three uses:
1. Octreotide SUN is used to treat acromegaly.
In people with acromegaly the body makes too much growth
hormone, which controls the
growth of tissues, organs and bones.
This leads to enlargement of the bones, especially of
the hands and feet. Other symptoms include headaches, increased
sweating, tiredness,
numbness of the hands and feet, pain and stiffness in
the joints and loss of sexual
function. By blocking the excess growth hormone, Octreotide
SUN can relieve many of
these symptoms.
2. Octreotide
SUN is used to relieve symptoms of certain types of cancer such as
carcinoid syndrome and VIPoma.
By blocking hormones that are over-produc
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PRODUCT INFORMATION
OCTREOTIDE SUN SOLUTION FOR INJECTION
NAME OF THE MEDICINE
Octreotide
Chemical name: D-Phenylalanyl-L-cysteinyl-L-phenyalanyl-D-tryptophyl-L-Iysyl-L-threonyl-N-[2-
hydroxy-1-(hydroxymethyl)propyl]-L-cysteinamide cyclic (27)–disulfide.
DESCRIPTION
Octreotide
SUN is octreotide, a synthetic octapeptide analogue of somatostatin.
where x = 1.4 to 2.5
CAS number: 79517-01-4. (octreotide acetate)
MW: 1019.3 (free peptide)
Each 1 mL ampoule contains 0.05 mg, 0.1 mg or 0.5
mg octreotide (present as acetate). The solution is
clear and colourless.
EXCIPIENTS: lactic acid, mannitol, sodium bicarbonate,
water for injections.
PHARMACOLOGY
PHARMACODYNAMICS
Octreotide is a synthetic octapeptide analogue
of naturally occurring somatostatin with similar
pharmacological effects, but with a considerably prolonged
duration of action. It inhibits the secretion of
serotonin and the gastro-entero-pancreatic peptides: gastrin,
vasoactive intestinal peptide, insulin, glucagon,
secretin, motilin, and pancreatic polypeptide, and of growth
hormone (GH). Octreotide, like somatostatin,
decreases splanchnic blood flow.
In animals, octreotide is a more potent inhibitor of growth
hormone, glucagon and insulin release than
somatostatin with greater selectivity for GH-and
glucagon-suppression.
In healthy subjects octreotide, like somatostatin, has been shown
to inhibit:
• release of growth hormone (GH) stimulated by arginine,
exercise and insulin-induced
hypoglycaemia
• postprandial release of insulin,
glucagon, gastrin, other peptides of the GEP system, and
arginine-
stimulated release of insulin and glucagon
• thyrotropin releasing hormone (TRH) stimulated release of thyroid stimulating hormone (TSH).
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