Octreotide Sun

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Octreotide

Available from:

Sun Pharmaceuticals Industries Australia Pty Ltd

Class:

Medicine Registered

Patient Information leaflet

Octreotide SUN_CMI_20120203                           

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OCTREOTIDE SUN 
_Octreotide _
_ _
WHAT IS IN THIS LEAFLET 
This leaflet answers some common questions about Octreotide SUN.
The information in 
this leaflet was last updated on the date listed
on the final page. More recent information 
on the medicine may be available. 

YOU SHOULD ENSURE THAT YOU SPEAK TO
YOUR PHARMACIST OR DOCTOR TO OBTAIN THE MOST 
UP TO DATE INFORMATION ON THE MEDICINE.  

Those updates may contain important information
about the medicine and its use of 
which you should be aware. It does not contain
all the available information. It does not 
take the place of talking to your doctor or pharmacist.
All medicines have risks and 
benefits. Your doctor has weighed the risks of you
using Octreotide SUN  against the 
benefits they expect it will have for you. 

IF YOU HAVE ANY CONCERNS ABOUT USING THIS MEDICINE,
ASK YOUR DOCTOR OR PHARMACIST. 
KEEP THIS LEAFLET WITH THE MEDICINE. 

You may need to read it again. 

WHAT OCTREOTIDE SUN IS USED FOR  
Octreotide SUN has three uses:  

1. Octreotide SUN is used to treat acromegaly. 
In people with acromegaly the body makes too much growth
hormone, which controls the 
growth of tissues, organs and bones.
This leads to enlargement of the bones, especially of 
the hands and feet. Other symptoms include headaches, increased
sweating, tiredness, 
numbness of the hands and feet, pain and stiffness in
the joints and loss of sexual 
function. By blocking the excess growth hormone, Octreotide
SUN can relieve many of 
these symptoms.  

2.  Octreotide
SUN  is used to relieve symptoms of certain types of cancer such as 
carcinoid syndrome and VIPoma.  
By blocking hormones that are over-produc

Summary of Product characteristics

Octreotide_PI 
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PRODUCT INFORMATION 

OCTREOTIDE SUN SOLUTION FOR INJECTION  

NAME OF THE MEDICINE 

Octreotide 

Chemical name: D-Phenylalanyl-L-cysteinyl-L-phenyalanyl-D-tryptophyl-L-Iysyl-L-threonyl-N-[2-
hydroxy-1-(hydroxymethyl)propyl]-L-cysteinamide cyclic (27)–disulfide. 

DESCRIPTION  
Octreotide
SUN is octreotide, a synthetic octapeptide analogue of somatostatin. 

where x = 1.4 to 2.5  

CAS number: 79517-01-4. (octreotide acetate)  
MW: 1019.3 (free peptide)  
Each 1 mL ampoule contains 0.05 mg, 0.1 mg or 0.5
mg  octreotide (present as acetate). The solution is 
clear and colourless.  
EXCIPIENTS: lactic acid, mannitol, sodium bicarbonate,
water for injections. 

PHARMACOLOGY 

PHARMACODYNAMICS 
Octreotide is a synthetic octapeptide analogue
of naturally occurring somatostatin with similar 
pharmacological effects, but with a considerably prolonged
duration of action. It inhibits the secretion of 
serotonin and the gastro-entero-pancreatic peptides: gastrin,
vasoactive intestinal peptide, insulin, glucagon, 
secretin, motilin, and pancreatic polypeptide, and of growth
hormone (GH). Octreotide, like somatostatin, 
decreases splanchnic blood flow. 

In animals, octreotide is a more potent inhibitor of growth
hormone, glucagon and insulin release than 
somatostatin with greater selectivity for GH-and
glucagon-suppression. 

In healthy subjects octreotide, like somatostatin, has been shown
to inhibit: 
•  release of growth hormone (GH) stimulated by arginine,
exercise and insulin-induced 
hypoglycaemia 
•  postprandial release of insulin,
glucagon, gastrin, other peptides of the GEP system, and
arginine-
stimulated release of insulin and glucagon 
•  thyrotropin releasing hormone (TRH) stimulated release of thyroid stimulating hormone (TSH).  

Octreotide_PI 
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