Ülke: Malezya
Dil: İngilizce
Kaynak: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
ALLOPURINOL
HOVID BERHAD
ALLOPURINOL
100 Tablets; 100 Tablets; 1000 Tablets
HOVID BERHAD
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_ HOVID ALLOPURINOL TABLET 100MG HOVID ALLOPURINOL (100 MG) 1 WHAT IS IN THIS LEAFLET 1. What Hovid Allopurinol is used for 2. How Hovid Allopurinol works 3. Before you use Hovid Allopurinol 4. How to take Hovid Allopurinol 5. While you are using Hovid Allopurinol 6. Side effects 7. Storage and Disposal of Hovid Allopurinol 8. Product description 9. Manufacturer and Product Registration Holder 10. Date of revision WHAT HOVID ALLOPURINOL IS USED FOR Used to treat: • Chronic primary or secondary gout or gouty arthritis (a condition of painful swollen joints caused by uric acid crystals) • Uric acid nephropathy and uric acid stones (uric acid crystals in the kidney) • Problems associated with hyperuricemia (level of uric acid in the blood that is abnormally high) HOW HOVID ALLOPURINOL WORKS This medicine belongs to a group of medicines called anti-uricaemics. These medicines work by reducing the formation and accumulation of uric acid in the body. Excess amounts of uric acid in the blood may lead to the development of crystals which deposit in the joints, causing pain, swelling and tenderness. BEFORE YOU USE HOVID ALLOPURINOL _- When you must not use it _ _ _ Do not take this medicine if: • you are hypersensitive to Allopurinol or any of the other ingredients of this product . • you or a member of your immediate family have haemochromatosis, a condition where there is too much iron in the body, and you are also taking iron salts at the same time • you are having an acute attack of gout. _- Before you start to use it_ _ _ Tell your doctor if: • you are allergic to any other medicines, foods, dyes or preservatives. • you are pregnant or plan to become pregnant • you are breastfeeding or wish to breastfeed • you plan to have surgery • you have the following medical condition: • liver problems • kidney problems • high blood pressure • heart failure or other heart problems • diabetes mellitus • cancer or tumours. _- Taking other medicines _ Belgenin tamamını okuyun
VIALL03-var (MY) HOVID ALLOPURINOL TABLET DESCRIPTION Round, white uncoated tablet, bevel-edged, flat faces, "HD" and break-bar embossed on the same face. COMPOSITION Each tablet contains: Allopurinol 100 mg / tablet. PHARMACODYNAMICS Allopurinol is a structural isomer of hypoxanthine. The affinity of allopurinol for xanthine oxidase is much greater than that of xanthine. Allopurinol is of value in the treatment of gout because it is an inhibitor of xanthine oxidase, the enzyme responsible for converting xanthine and hypoxanthine to uric acid. Both Allopurinol and its major metabolite alloxanthine (oxypurinol) inhibit xanthine oxidase. Xanthine and hypoxanthine are more easily excreted than uric acid. Allopurinol decreases the rate of formation and the blood levels of uric acid considerably but does not appreciably affect that of the more water soluble xanthine. Body uric acid is therefore decreased by reducing uric acid formation. By lowering the serum concentration of uric acid below its solubility limits, allopurinol promotes the resolution of tophi and uric acid crystals. PHARMACOKINETICS ABSORPTION: Allopurinol is rapidly absorbed from the upper gastrointestinal tract and appears to be about 80% to 90% absorbed. BLOOD CONCENTRATION: 100 mg of Allopurinol administered thrice daily produced plasma concentrations of alloxanthine (oxipurinol), the major metabolite of allopurinol, of 5 to 15 microgram/ml, after one week. HALF-LIFE: Plasma half-life is about 1 to 3 hours for allopurinol and 12 to 30 hours for alloxanthine (oxipurinol). PROTEIN BINDING: Neither allopurinol nor its metabolite, oxipurinol, is bound to plasma proteins. DISTRIBUTION: Allopurinol is well distributed throughout the body water. Both allopurinol and alloxanthine (oxipurinol) are not bound to serum proteins and are excreted mainly in urine. Alloxanthine (oxipurinol) may accumulate in renal function impairment. METABOLISM: Allopurinol is rapidly oxidized in the liver to its active metabolite, alloxanthine (oxipurinol). EXCRETION: About 30% o Belgenin tamamını okuyun