Hovid Allopurinol Tablet 100mg

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

ALLOPURINOL

Boleh didapati daripada:

HOVID BERHAD

INN (Nama Antarabangsa):

ALLOPURINOL

Unit dalam pakej:

100 Tablets; 100 Tablets; 1000 Tablets

Dikeluarkan oleh:

HOVID BERHAD

Risalah maklumat

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_
HOVID ALLOPURINOL TABLET 100MG
HOVID ALLOPURINOL (100 MG)
1
WHAT IS IN THIS LEAFLET
1.
What Hovid Allopurinol is used for
2.
How Hovid Allopurinol works
3.
Before you use Hovid Allopurinol
4.
How to take Hovid Allopurinol
5.
While you are using Hovid
Allopurinol
6.
Side effects
7.
Storage and Disposal of Hovid
Allopurinol
8.
Product description
9.
Manufacturer and Product
Registration Holder
10.
Date of revision
WHAT HOVID ALLOPURINOL IS USED FOR
Used to treat:
•
Chronic primary or secondary
gout or gouty arthritis (a
condition of painful swollen
joints caused by uric acid
crystals)
•
Uric acid nephropathy and uric
acid stones (uric acid crystals in
the kidney)
•
Problems associated with
hyperuricemia (level of uric acid
in the blood that is abnormally
high)
HOW HOVID ALLOPURINOL WORKS
This medicine belongs to a group of
medicines called anti-uricaemics. These
medicines work by reducing the formation
and accumulation of uric acid in the body.
Excess amounts of uric acid in the blood
may lead to the development of crystals
which deposit in the joints, causing pain,
swelling and tenderness.
BEFORE YOU USE HOVID ALLOPURINOL
_- When you must not use it _
_ _
Do not take this medicine if:
•
you are hypersensitive to Allopurinol
or any of the other ingredients of this
product .
•
you or a member of your immediate
family have haemochromatosis, a
condition where there is too much
iron in the body, and you are also
taking iron salts at the same time
•
you are having an acute attack of
gout.
_- Before you start to use it_
_ _
Tell your doctor if:
•
you are allergic to any other
medicines, foods, dyes or
preservatives.
•
you are pregnant or plan to become
pregnant
•
you are breastfeeding or wish to
breastfeed
•
you plan to have surgery
•
you have the following medical
condition:
•
liver problems
•
kidney problems
•
high blood pressure
•
heart failure or other heart
problems
•
diabetes mellitus
•
cancer or tumours.
_- Taking other medicines _

Ciri produk

VIALL03-var (MY)
HOVID ALLOPURINOL TABLET
DESCRIPTION
Round, white uncoated tablet, bevel-edged, flat faces, "HD"
and break-bar embossed on the same face.
COMPOSITION
Each tablet contains:
Allopurinol 100 mg / tablet.
PHARMACODYNAMICS
Allopurinol is a structural isomer of hypoxanthine. The affinity
of allopurinol for xanthine oxidase is much greater than that of
xanthine. Allopurinol is of value in the treatment of gout because
it is an inhibitor of xanthine oxidase, the enzyme responsible
for converting xanthine and hypoxanthine to uric acid.
Both
Allopurinol
and
its
major
metabolite
alloxanthine
(oxypurinol) inhibit xanthine oxidase. Xanthine and hypoxanthine
are more easily excreted than uric acid. Allopurinol decreases
the
rate
of
formation
and
the
blood
levels
of
uric
acid
considerably but does not appreciably affect that of the more
water soluble xanthine. Body uric acid is therefore decreased
by
reducing
uric
acid
formation.
By
lowering
the
serum
concentration of uric acid below its solubility limits, allopurinol
promotes the resolution of tophi and uric acid crystals.
PHARMACOKINETICS
ABSORPTION: Allopurinol is rapidly absorbed from the upper
gastrointestinal tract and appears to be about 80% to 90%
absorbed.
BLOOD CONCENTRATION: 100 mg of Allopurinol administered
thrice daily produced plasma concentrations of alloxanthine
(oxipurinol), the major metabolite of allopurinol, of 5 to 15
microgram/ml, after one week.
HALF-LIFE: Plasma half-life is about 1 to 3 hours for allopurinol
and 12 to 30 hours for alloxanthine (oxipurinol).
PROTEIN
BINDING:
Neither
allopurinol
nor
its
metabolite,
oxipurinol, is bound to plasma proteins.
DISTRIBUTION: Allopurinol is well distributed throughout the body
water. Both allopurinol and alloxanthine (oxipurinol) are not
bound to serum proteins and are excreted mainly in urine.
Alloxanthine (oxipurinol) may accumulate in renal function
impairment.
METABOLISM: Allopurinol is rapidly oxidized in the liver to its
active metabolite, alloxanthine (oxipurinol).
EXCRETION: About 30% o