FLUIMUCIL GRANULES 200 mgsachet

Ülke: Singapur

Dil: İngilizce

Kaynak: HSA (Health Sciences Authority)

Aktif bileşen:

ACETYLCYSTEINE

Mevcut itibaren:

UNITED ITALIAN TRADING CORPORATION (PRIVATE) LIMITED

ATC kodu:

R05CB01

Doz:

200 mg/sachet

Farmasötik formu:

GRANULE

Kompozisyon:

ACETYLCYSTEINE 200 mg/sachet

Uygulama yolu:

ORAL

Reçete türü:

Pharmacy Only

Tarafından üretildi:

ZAMBON SWITZERLAND LTD

Yetkilendirme durumu:

ACTIVE

Yetkilendirme tarihi:

1989-06-17

Bilgilendirme broşürü

_Package Leaflet _
FLUIMUCIL®
FOR ORAL USE
PHARMACOLOGICAL PROPERTIES
Acetylcysteine (NAC), the active ingredient of FLUIMUCIL®, exerts an
intense mucolytic-
fluidifying
action
on
mucous
and
mucopurulent
secretions,
by
depolymerizing
the
mucoproteic complexes and the nucleic acids which confer viscosity to
the vitreous and
purulent component of the sputum and of other secretions.
Additional properties are: reduction of induced hyperplasia of mucous
cells, increase in
surfactant production by stimulation of type II pneumocytes,
stimulation of mucociliary
activity, leading to improved mucociliary clearance.
Furthermore, NAC, exerts a direct antioxidant action, being provided
with a free thiol (-SH
nucleophilic) group, which is able to interact directly with the
electrophilic groups of the
oxidant radicals. Of particular interest is the finding that NAC
protects the
∝
-1-antitrypsin,
enzyme inhibitor of elastase, from the inactivation due to the action
of hypochlorous acid
(HOCI), a powerful oxidant agent produced by the myeloperoxidase
enzyme of activated
phagocytes. Furthermore, Acetylcysteine exerts in addition an indirect
antioxidant effect
through its role as GSH precursor. Inside the cell, NAC is
deacetylized, forming L-cysteine, an
amino acid indispensable for the glutathione synthesis (GSH). GSH is a
highly reactive
tripeptide, found ubiquitously in the various tissues of animals and
is essential for the
maintenance
of
functional
capacity
as
well
as
cellular
morphological
integrity,
as
it
represents the most important protective, endocellular mechanism
against oxidant radicals,
either of external or internal nature as well as towards numerous
cytotoxic substances. NAC
plays
a
role of
primary
importance
in
the
maintenance
of
adequate
GSH
levels
thus
contributing to the cellular protections from harmful agents which,
through progressive GSH
depletion, would be able to express their cytotoxic actions, as in the
case of acetaminophen
poisoning. Due to this mechanism of action, NAC is also indicated as a
spec