Nazione: Singapore
Lingua: inglese
Fonte: HSA (Health Sciences Authority)
ACETYLCYSTEINE
UNITED ITALIAN TRADING CORPORATION (PRIVATE) LIMITED
R05CB01
200 mg/sachet
GRANULE
ACETYLCYSTEINE 200 mg/sachet
ORAL
Pharmacy Only
ZAMBON SWITZERLAND LTD
ACTIVE
1989-06-17
_Package Leaflet _ FLUIMUCIL® FOR ORAL USE PHARMACOLOGICAL PROPERTIES Acetylcysteine (NAC), the active ingredient of FLUIMUCIL®, exerts an intense mucolytic- fluidifying action on mucous and mucopurulent secretions, by depolymerizing the mucoproteic complexes and the nucleic acids which confer viscosity to the vitreous and purulent component of the sputum and of other secretions. Additional properties are: reduction of induced hyperplasia of mucous cells, increase in surfactant production by stimulation of type II pneumocytes, stimulation of mucociliary activity, leading to improved mucociliary clearance. Furthermore, NAC, exerts a direct antioxidant action, being provided with a free thiol (-SH nucleophilic) group, which is able to interact directly with the electrophilic groups of the oxidant radicals. Of particular interest is the finding that NAC protects the ∝ -1-antitrypsin, enzyme inhibitor of elastase, from the inactivation due to the action of hypochlorous acid (HOCI), a powerful oxidant agent produced by the myeloperoxidase enzyme of activated phagocytes. Furthermore, Acetylcysteine exerts in addition an indirect antioxidant effect through its role as GSH precursor. Inside the cell, NAC is deacetylized, forming L-cysteine, an amino acid indispensable for the glutathione synthesis (GSH). GSH is a highly reactive tripeptide, found ubiquitously in the various tissues of animals and is essential for the maintenance of functional capacity as well as cellular morphological integrity, as it represents the most important protective, endocellular mechanism against oxidant radicals, either of external or internal nature as well as towards numerous cytotoxic substances. NAC plays a role of primary importance in the maintenance of adequate GSH levels thus contributing to the cellular protections from harmful agents which, through progressive GSH depletion, would be able to express their cytotoxic actions, as in the case of acetaminophen poisoning. Due to this mechanism of action, NAC is also indicated as a spec Leggi il documento completo