Ülke: Avustralya
Dil: İngilizce
Kaynak: Department of Health (Therapeutic Goods Administration)
Carboplatin
Accord Healthcare Pty Ltd
Medicine Registered
CARBACCORD 10 MG/ML CARBOPLATIN SOLUTION FOR INJECTION 5 ML, 15 ML AND 45 ML VIAL CONSUMER MEDICINE INFORMATION VERSION-1.0 2011 Page 1 of 5 CARBACCORD (CARBOPLATIN) INJECTION 10 MG/ML, 5 ML, 15 ML AND 45 ML Carboplatin _(carb-o-PLAT-in)_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Carbaccord (carboplatin) Injection. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you being given carboplatin against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT BEING GIVEN THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET. You may need to read it again. WHAT CARBACCORD (CARBOPLATIN) INJECTION IS USED FOR This medicine is used to treat: • ovarian cancer • cancer of the testes • some types of lung cancer • cancer of the brain and/or spinal cord • cancer of the head and neck • neuroblastoma (a cancer of the nerves and adrenal glands) • a type of cancer called sarcoma. Carboplatin belongs to a group of medicines called antineoplastic or cytotoxic medicines. You may also hear of these being called chemotherapy medicines. This medicine is classified Belgenin tamamını okuyun
CARBACCORD 10 mg/mL carboplatin solution for injection 5 mL, 15 mL and 45 mL vial Version-1.0 2011 Page 1 of 10 PRODUCT INFORMATION CARBACCORD (CARBOPLATIN) SOLUTION FOR INJECTION NAME OF THE MEDICINE Carboplatin TRADE NAME CARBACCORD Solution for Injection DESCRIPTION Carboplatin is (SP-4-2)-diammine[cyclobutan-1,1-dicarboxylato(2-)-0,0’]platin. It is a colourless, crystalline powder, sparingly soluble in water, very slightly soluble in acetone and in alcohol. The chemical structure of carboplatin is shown below: Molecular Formula: C 6 H 12 N 2 O 4 Pt Molecular Weight: 371.3 CAS Number: 41575-94-4 Carboplatin Solution for Injection is a sterile, hypotonic, preservative-free solution of carboplatin in Water for Injections Ph. Eur. The pH of the injection ranges between 5.0 and 7.0. Carboplatin Solution for Injection is presented in vials containing 50 mg/5 mL, 150 mg/15 mL and 450 mg/45 mL. PHARMACOLOGY Carboplatin, an analogue of cisplatin, is an antineoplastic agent which interferes with DNA intrastrand and interstrand crosslinks in cells exposed to the medicine. DNA reactivity has been correlated with cytotoxicity. PHARMACOKINETICS After a one-hour infusion of the medicine (dose range 20 to 520 milligrams/m 2 ) plasma levels of total platinum and ultrafilterable (free) platinum decay biphasically following first order kinetics. For ultrafilterable platinum reported values for the initial phase of the half life (t alpha 1/2 ) are about 90 minutes and in the later phase t Belgenin tamamını okuyun