ประเทศ: สิงคโปร์
ภาษา: อังกฤษ
แหล่งที่มา: HSA (Health Sciences Authority)
FLUOXETINE ( as HCl)
TEVA PHARMACEUTICAL INVESTMENTS SINGAPORE PTE. LTD.
N06AB03
20 mg
CAPSULE
FLUOXETINE ( as HCl) 20 mg
ORAL
Prescription Only
TEVA PHARMACEUTICAL INDUSTRIES LTD
ACTIVE
2003-06-05
AAAO2168 - FLUOXETINE 20 MG, PIL, SINGAPORE 02 4.05.2022 InA 18.05.2022 InA 160x560 mm Teva Israel 8 pt Black FLUOXETINE-TEVA 20 MG CAPSULES COMPOSITION Each capsule contains: Active Ingredient Fluoxetine (as hydrochloride) 20 mg _Other Ingredients:_ Simethicone emulsion, colloidal silicon dioxide, pregelatinized starch. MECHANISM OF ACTION Fluoxetine is an antidepressant which is chemically unrelated to tetracyclic or other available antidepressant agents. The mechanism of action of fluoxetine is complex and in some ways resembles that of other antidepressant agents, particularly those agents (e.g., clomipramine, trazodone) that predominantly potentiate the pharmacologic effects of serotonin. Unlike other currently available serotonin-enhancing antidepressant agents, fluoxetine is a highly selective reuptake inhibitor of serotonin and has little or no effect on other neurotransmitters. _PHARMACODYNAMICS_ _Central Nervous System Effects_ The precise mechanism of antidepressant action of fluoxetine is unclear, but the drug has been shown to selectively inhibit the reuptake of serotonin (5-HT) at the presynaptic neuronal membrane. Fluoxetine- induced inhibition of serotonin reuptake causes increased synaptic concentrations of serotonin in the CNS, resulting in numerous functional changes associated with enhanced serotonergic neurotransmission. Unlike most other current available antidepressant agents, fluoxetine appears to have minimal or no effect on the reuptake of norepinephrine or dopamine and does not exhibit clinically important anticholinergic, antihistaminic, or (alpha)1- adrenergic blocking activity at usual therapeutic dosages. _Cardiovascular Effects_ The cardiovascular effects of fluoxetine have been studied in animals and to a limited extent in humans. Unlike most other antidepressant agents (e.g., tricyclic antidepressants, MAO inhibitors), fluoxetine has been associated with only minimal cardiovascular effects. The absence of substantial activity, (alpha)1-adrenergic blocking activity, catecholamine- อ่านเอกสารฉบับเต็ม