Nchi: Australia
Lugha: Kiingereza
Chanzo: Department of Health (Therapeutic Goods Administration)
Dextropropoxyphene hydrochloride; Paracetamol
PARADEX ® _dextropropoxyphene hydrochloride with paracetamol_ CONSUMER MEDICINE INFORMATION (CMI) WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Paradex. It does not contain all the available information and does not take the place of talking to your doctor. All medicines have risks and benefits. Your doctor has weighed the risks of you taking Paradex against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again. WHAT PARADEX IS USED FOR Paradex is used for the relief of mild to moderate pain. Paradex contains two active ingredients, dextropropoxyphene hydrochloride and paracetamol. Both drugs have pain relieving properties, however, the combination of the two drugs produces greater pain relief than if either drug was taken alone. Dextropropoxyphene hydrochloride works by affecting the body's feeling and response to pain. It acts on certain receptors on the nerves. Paracetamol acts on certain chemicals in the nerves and blocks pain impulses. Paracetamol can also reduce fever. Paradex may be habit forming so it is important to take it exactly as directed by your doctor. ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY PARADEX HAS BEEN PRESCRIBED FOR YOU. Your doctor may have prescribed it for another reason. This medicine is available only with a doctor's prescription. BEFORE YOU TAKE IT _WHEN YOU MUST NOT TAKE IT_ DO NOT TAKE PARADEX IF YOU HAVE EVER HAD AN ALLERGY TO IT OR TO ANY OF THE INGREDIENTS LISTED AT THE END OF THIS LEAFLET. Symptoms of an allergic reaction may include shortness of breath, wheezing or difficulty breathing; swelling of the face, lips, tongue or other parts of the body; skin rash, itching or hives. DO NOT TAKE PARADEX IF YOU HAVE A HISTORY OF ALCOHOLISM OR SUBSTANCE ABUSE. DO NOT TAKE PARADEX IF YOU HAVE EVER BEEN SUICIDAL. DO NOT TAKE OTHER PARACETAMOL CONTAINING PRODUCTS AT THE SAME TIME AS PARADEX. D Soma hati kamili
PRODUCT INFORMATION _PARADEX _ NAME OF THE DRUG: Dextropropoxyphene Hydrochloride; Paracetamol STRUCTURAL FORMULAE Dextropropoxyphene Hydrochloride CAS-1639-60-7 Paracetamol CAS-103-90-2 DESCRIPTION: Dextropropoxyphene Hydrochloride 32.5 mg, Mol. Wt. 375.9, C 22 H 29 NO 2 ,HCl is (1S, 2R)- 1-benzyl-3-dimethylamino-2-methyl-1-phenylpropyl propionate hydrochloride. Paracetamol 325 mg, Mol. Wt. 151.2,_ _C 8 H 9 NO 2 is N-(4-hydroxyphenyl) acetamide_._ Dextropropoxyphene hydrochloride occurs as a white or slightly yellow powder, odourless, and with a bitter taste. It is soluble in 0.3 parts of water, 1 in 1 - 5 parts of alcohol (95%) and 1 in 0.6 parts of chloroform. It is insoluble in solvent ether. It has a melting point of about 165 o . Paracetamol occurs as white crystals or a white crystalline powder; odourless and with a bitter taste. It is soluble 1 in 70 parts of water, 1 in 7 parts of alcohol (95%), 1 in 13 parts of acetone, 1 in 40 parts of glycerol, and 1 in 9 parts of propylene glycol; it is also soluble in solutions of the alkali hydroxides. It has a melting point of 169 o to 172 o . EXCIPIENTS: Lactose BP, Starch-wheat_,_ Starch–pregelatinised wheat, Silica–colloidal anhydrous, Talc- purified, Ethylcellulose, Sodium starch glycollate, Povidone and Magnesium stearate. PARADEX Product Information – Full & Marketed Page 1 of 8 PHARMACOLOGY: ACTIONS: _Dextropropoxyphene hydrochloride_ is a centrally acting, synthetic opioid analgesic structurally related to methadone. It binds to opioid receptors at many sites within the central nervous system affecting processes for both the physiological perception of pain and the emotional response to pain. There are multiple subtypes of central and peripheral opioid receptors each mediating therapeutic and/or adverse effects of opioid drugs. The potency o Soma hati kamili