Paradex

Šalis: Australija

kalba: anglų

Šaltinis: Department of Health (Therapeutic Goods Administration)

Veiklioji medžiaga:

Dextropropoxyphene hydrochloride; Paracetamol

Pakuotės lapelis

PARADEX
®

_dextropropoxyphene hydrochloride with paracetamol_
CONSUMER MEDICINE INFORMATION (CMI)

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Paradex. It does not
contain all the available information
and does not take the place of talking
to your doctor.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking Paradex
against the benefits they expect it
will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT PARADEX IS USED
FOR
Paradex is used for the relief of mild
to moderate pain.
Paradex contains two active
ingredients, dextropropoxyphene
hydrochloride and paracetamol. Both
drugs have pain relieving properties,
however, the combination of the two
drugs produces greater pain relief
than if either drug was taken alone.
Dextropropoxyphene hydrochloride
works by affecting the body's feeling
and response to pain. It acts on
certain receptors on the nerves.
Paracetamol acts on certain
chemicals in the nerves and blocks
pain impulses. Paracetamol can also
reduce fever.
Paradex may be habit forming so it is
important to take it exactly as
directed by your doctor.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY PARADEX HAS
BEEN PRESCRIBED FOR YOU.
Your doctor may have prescribed it
for another reason.
This medicine is available only with
a doctor's prescription.
BEFORE YOU TAKE IT
_WHEN YOU MUST NOT TAKE IT_
DO NOT TAKE PARADEX IF YOU HAVE
EVER HAD AN ALLERGY TO IT OR TO ANY
OF THE INGREDIENTS LISTED AT THE END
OF THIS LEAFLET.
Symptoms of an allergic reaction
may include shortness of breath,
wheezing or difficulty breathing;
swelling of the face, lips, tongue or
other parts of the body; skin rash,
itching or hives.
DO NOT TAKE PARADEX IF YOU HAVE A
HISTORY OF ALCOHOLISM OR SUBSTANCE
ABUSE.
DO NOT TAKE PARADEX IF YOU HAVE
EVER BEEN SUICIDAL.
DO NOT TAKE OTHER PARACETAMOL
CONTAINING PRODUCTS AT THE SAME
TIME AS PARADEX.
D

Prekės savybės

 
PRODUCT INFORMATION 

_PARADEX  _

NAME OF THE DRUG: 

Dextropropoxyphene Hydrochloride; Paracetamol 

STRUCTURAL FORMULAE 

Dextropropoxyphene Hydrochloride 

CAS-1639-60-7 

Paracetamol 

CAS-103-90-2 

DESCRIPTION:
Dextropropoxyphene Hydrochloride 32.5 mg, Mol. Wt. 375.9, C
22
H
29
NO
2
,HCl is (1S, 2R)-
1-benzyl-3-dimethylamino-2-methyl-1-phenylpropyl propionate
hydrochloride. 

Paracetamol 325 mg, Mol. Wt. 151.2,_ _C
8
H
9
NO
2
 is N-(4-hydroxyphenyl) acetamide_._ 

Dextropropoxyphene hydrochloride occurs as a white
or slightly yellow powder, 
odourless, and with a bitter taste.  It is soluble in 0.3 parts of
water, 1 in 1 - 5 parts of 
alcohol (95%) and 1 in 0.6 parts of chloroform.  It is
insoluble in solvent ether.  It has a 
melting point of about 165
o
.  Paracetamol occurs as white crystals or a white crystalline 
powder; odourless and with a bitter taste.  It is soluble 1 in
70 parts of water, 1 in 7 parts 
of alcohol (95%), 1 in 13 parts of acetone, 1 in
40 parts of glycerol, and 1 in 9 parts of 
propylene glycol; it is also soluble in solutions of the alkali
hydroxides.  It has a melting 
point of 169
o
 to 172
o
. 

EXCIPIENTS: 
Lactose BP, Starch-wheat_,_ Starch–pregelatinised wheat,
Silica–colloidal anhydrous, Talc-
purified, Ethylcellulose, Sodium starch glycollate, Povidone and
Magnesium stearate. 
PARADEX Product Information – Full & Marketed 

Page 1 of 8 

PHARMACOLOGY:  
ACTIONS: 

_Dextropropoxyphene hydrochloride_ is a centrally
acting, synthetic opioid analgesic 
structurally related to methadone.  It binds to opioid
receptors at many sites within the 
central nervous system affecting processes for both the physiological
perception of pain 
and the emotional response to pain.  There are multiple subtypes
of central and 
peripheral opioid receptors each mediating therapeutic and/or adverse
effects of opioid 
drugs.  The potency o