Nchi: Marekani
Lugha: Kiingereza
Chanzo: NLM (National Library of Medicine)
FUROSEMIDE (UNII: 7LXU5N7ZO5) (FUROSEMIDE - UNII:7LXU5N7ZO5)
MWI/VetOne
FUROSEMIDE
FUROSEMIDE 12.5 mg
ORAL
PRESCRIPTION
Dogs - Furosemide Tablets are indicated for the treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency and acute non-inflammatory tissue edema. In cases of edema involving cardiac insufficiency, the continued use of heart stimulants such as digitalis or its glycosides is indicated. The rationale for efficacious use of diuretic therapy is determined by the clinical pathology producing the edema. Animal reproductive studies have shown that furosemide may cause fetal abnormality and the drug is contraindicated in pregnant animals. Furosemide is contraindicated in anuria, furosemide hypersensitivity, hepatic coma, or during electrolytic imbalances. Monitor serum electrolytes, BUN and CO2 frequently. Monitor serum potassium levels and watch for signs of hypocalcemia. Corticosteroids cause an additive potassium-depletion effect.
Furosemide Tablets are available in 12.5 mg and 50 mg strength and supplied in bottles containing 500 tablets. NDC 13985-586-12 - 12.5 mg – 500 tablets NDC 13985-585-50 - 50 mg – 500 tablets
New Animal Drug Application
FUROSEMIDE- FUROSEMIDE TABLET MWI/VETONE ---------- FUROSEMIDE TABLETS Approved by FDA under NADA # 129-034 Furosemide is not USP for dissolution. For use in dogs only. CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION: Furosemide is a potent loop diuretic which is a derivative of anthranilic acid. The structure is: CHEMICAL NAME: 4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid. Furosemide is pharmacodynamically characterized by the following: 1) It is administered orally. It is easily absorbed from the intestinal tract and begins to act in 30 to 60 minutes after oral administration. 2) Is a loop diuretic which inhibits reabsorption of sodium and chloride at the ascending loop of Henle in the kidneys, enhancing water excretion. 3) A dose-response relationship and a ratio of minimum to maximum effective dose range greater than tenfold. 4) A high degree of efficacy, low inherent toxicity and a high therapeutic index. ACTIONS: The therapeutic efficacy of Furosemide Tablets is from the activity of the intact and unaltered molecule throughout the nephron, inhibiting the reabsorption of sodium not only in the proximal and distal tubule but also in the ascending limb of the loop of Henle. The prompt onset of action is a result of the drug's rapid absorption and a poor lipid solubility. The low lipid solubility and a rapid renal excretion minimize the possibility of its 1, 2 3 1 solubility. The low lipid solubility and a rapid renal excretion minimize the possibility of its accumulation in tissues and organs or crystalluria. Furosemide Tablets have no inhibitory effect on carbonic anhydrase or aldosterone activity in the distal tubule. The drug possesses diuretic activity either in the presence of acidosis or alkalosis. INDICATIONS: Dogs - Furosemide Tablets are indicated for the treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency and acute non-inflammatory tissue edema. In cases of edema involving cardiac insufficiency, the con Soma hati kamili