Nchi: Malesia
Lugha: Kiingereza
Chanzo: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
FLUMEQUINE
Shennong Animal Health (Malaysia) Sdn. Bhd.
FLUMEQUINE
1000.00 mcg/mL
Shennong Animal Health (Malaysia) Sdn. Bhd.
FLUMEQUINE 20% LIQUID SOLUTION Liquid Solution (FOR VETERINARY USE ONLY) COMPOSITION Flumequine ………………………………………………200 g/L PRODUCT DESCRIPTION The finished product is light yellowish colored solution PHARMACODYNAMICS Flumequine is an anti-infective for the synthesis of quinolone. It acts on the nucleic acid level by blocking DNA replication in bacteria. The molecular target is DNA gyrase, involved in the spiral winding of DNA. Flumequine has a dose-dependent bactericidal activity against Gram-negative. It has also an effect on some Gram-positive bacteria (including staphylococci) PHARMACOKINETICS Flumequine is very often well absorbed after administration of oral specialty. Its bioavailability is approximately 76-100% in calves, 57% in chickens, 7% in pigeons. Tmax was reached after about 2-3 hours and Cmax varies between species and specialty. The rate of protein binding of flumequine is relatively high (75% calves, 39% in pigeons). Pharmacokinetic parameters are linearly correlated to doses administered flumequine. No accumulation in the blood or enzyme induction or inhibition is observed. Flumequine is metabolized in the liver mainly 7-hydroxy-flumequine and flumequine secondarily glucuronide. It undergoes a relatively rapid elimination phase. Its half-life is approximately 1.5 hours in the pigeon, 2 h in calves, 7 pm in the chicken. Flumequine is mainly excreted in the urine as glucuronide flumequine and flumequine. INDICATIONS Specific indications for poultry are: - respiratory tract infections caused by Pasteurella multocida; - enteritis caused by E. coli and Salmonella spp. CONTRA-INDICATIONS Not to be used along with, trimethoprim and sulfonamides. Do not use in laying hens producing egg for human consumption. Do not use in animals know to have hypersensitivity to quinolones. ADMINISTRATION & DOSAGE In poultry: 12 mg of flumequine per kg of bodyweight per day for 5 days orally. The amount of drinking water consumed by animals depends on their physiological and clinical c Soma hati kamili