Flumequine 20% Liquid Solution

Šalis: Malaizija

kalba: anglų

Šaltinis: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Veiklioji medžiaga:

FLUMEQUINE

Prieinama:

Shennong Animal Health (Malaysia) Sdn. Bhd.

INN (Tarptautinis Pavadinimas):

FLUMEQUINE

Vienetai pakuotėje:

1000.00 mcg/mL

Pagaminta:

Shennong Animal Health (Malaysia) Sdn. Bhd.

Prekės savybės

FLUMEQUINE 20% LIQUID SOLUTION
Liquid Solution
(FOR VETERINARY USE ONLY)
COMPOSITION
Flumequine ………………………………………………200
g/L
PRODUCT DESCRIPTION
The finished product is light yellowish colored solution
PHARMACODYNAMICS
Flumequine is an anti-infective for the synthesis of quinolone. It
acts on the nucleic acid level by blocking
DNA replication in bacteria. The molecular target is DNA gyrase,
involved in the spiral winding of DNA.
Flumequine has a dose-dependent bactericidal activity against
Gram-negative. It has also an effect on
some Gram-positive bacteria (including staphylococci)
PHARMACOKINETICS
Flumequine is very often well absorbed after administration of oral
specialty. Its bioavailability is
approximately 76-100% in calves, 57% in chickens, 7% in pigeons. Tmax
was reached after about 2-3
hours and Cmax varies between species and specialty. The rate of
protein binding of flumequine is
relatively high (75% calves, 39% in pigeons). Pharmacokinetic
parameters are linearly correlated to
doses administered flumequine. No accumulation in the blood or enzyme
induction or inhibition is
observed. Flumequine is metabolized in the liver mainly
7-hydroxy-flumequine and flumequine
secondarily glucuronide. It undergoes a relatively rapid elimination
phase. Its half-life is approximately
1.5 hours in the pigeon, 2 h in calves, 7 pm in the chicken.
Flumequine is mainly excreted in the urine as
glucuronide flumequine and flumequine.
INDICATIONS
Specific indications for poultry are: - respiratory tract infections
caused by Pasteurella multocida; -
enteritis caused by E. coli and Salmonella spp.
CONTRA-INDICATIONS
Not to be used along with, trimethoprim and sulfonamides. Do not use
in laying hens producing egg for
human consumption. Do not use in animals know to have hypersensitivity
to quinolones.
ADMINISTRATION & DOSAGE
In poultry: 12 mg of flumequine per kg of bodyweight per day for 5
days orally. The amount of drinking
water consumed by animals depends on their physiological and clinical
c