Nchi: Australia
Lugha: Kiingereza
Chanzo: Department of Health (Therapeutic Goods Administration)
Fludarabine phosphate
Sandoz Pty Ltd
Medicine Registered
Product Information Fludarabine Ebewe 50mg/2mL injection vial 08/2011 1 PRODUCT INFORMATION FLUDARABINE EBEWE 50 MG/2 ML INJECTION NAME OF THE MEDICINE Fludarabine phosphate Chemical Name: 2-Fluoro-9(5-O-phosphono-β-D-arabinofuranosyl)-9H-purin-6-amine Molecular formula: C 10 H 13 FN 5 O 7 P Molecular weight: 365.2 CAS number: 75607-67-9 DESCRIPTION Fludarabine phosphate is a white or almost white, hygroscopic crystalline powder, slightly soluble in water, freely soluble in dimethylformamide, and very slightly soluble in anhydrous ethanol. Fludarabine Ebewe is a sterile, clear, colourless solution containing 50mg fludarabine phosphate, sodium phosphate – dibasic dihydrate, and sodium hydroxide in water for injections. PHARMACOLOGY Fludarabine phosphate is a fluorinated nucleotide analogue of the antiviral agent vidarabine, (9- -D-arabinofuranosyladenine) that is relatively resistant to deamination by adenosine deaminase. Fludarabine phosphate is rapidly dephosphorylated to fludarabine (2F-ara-A) which is taken up by cells and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, fludarabine triphosphate (2F-ara-ATP). This metabolite has been shown to inhibit ribonucleotide reductase, DNA polymerase , and , DNA primase and DNA ligase thereby inhibiting DNA synthesis. Furthermore, partial inhibition of RNA polymerase II and consequent reduction in protein synthesis occurs. Product Information Soma hati kamili