Fludarabine Ebewe

Pajjiż: Awstralja

Lingwa: Ingliż

Sors: Department of Health (Therapeutic Goods Administration)

Ingredjent attiv:

Fludarabine phosphate

Disponibbli minn:

Sandoz Pty Ltd

Klassi:

Medicine Registered

Karatteristiċi tal-prodott

Product Information                                                                                                                                   
Fludarabine Ebewe 50mg/2mL injection vial 
08/2011           

1 

PRODUCT INFORMATION

FLUDARABINE EBEWE 50 MG/2 ML INJECTION 

NAME OF THE MEDICINE 
Fludarabine phosphate  

Chemical Name:
2-Fluoro-9(5-O-phosphono-β-D-arabinofuranosyl)-9H-purin-6-amine 
Molecular formula: C
10
H
13
FN
5
O
7
P 
Molecular weight: 365.2 
CAS number: 75607-67-9 
DESCRIPTION 
Fludarabine phosphate is a white or almost white, hygroscopic
crystalline powder, slightly 
soluble in water, freely soluble in dimethylformamide, and
very slightly soluble in anhydrous 
ethanol. 
Fludarabine Ebewe is a sterile, clear, colourless solution
containing 50mg fludarabine 
phosphate, sodium phosphate – dibasic
dihydrate, and sodium hydroxide in water for 
injections.  
PHARMACOLOGY 
Fludarabine phosphate is a fluorinated
nucleotide analogue of the antiviral agent vidarabine, 
(9-

-D-arabinofuranosyladenine) that is relatively resistant to
deamination by adenosine 
deaminase. 
Fludarabine phosphate is rapidly dephosphorylated to fludarabine
(2F-ara-A) which is taken 
up by cells and then phosphorylated
intracellularly by deoxycytidine kinase to the active 
triphosphate, fludarabine triphosphate (2F-ara-ATP). This
metabolite has been shown to 
inhibit ribonucleotide reductase, DNA polymerase 

, 

 and 

, DNA primase and DNA ligase 
thereby inhibiting DNA synthesis. Furthermore, partial inhibition of
RNA polymerase II and 
consequent reduction in protein synthesis occurs.  
Product Information