Nchi: Australia
Lugha: Kiingereza
Chanzo: Department of Health (Therapeutic Goods Administration)
Bleomycin sulfate
Aspen Pharma Pty Ltd
Medicine Registered
BLENAMAX- Product Information Page 1 of 8 PRODUCT INFORMATION BLENAMAX ® POWDER FOR INJECTION NAME OF THE DRUG BLENAMAX ® (bleomycin sulfate) 15,000 IU powder for injection DESCRIPTION Bleomycin sulfate is an antineoplastic antibiotic. It is the sulfate of a mixture of glycopeptides isolated from a strain of _Streptomyces verticillus _; the two principal components of the mixture are bleomycin A2 and B2. The CAS No. of bleomycin sulfate is 9041-34-4. The chemical structure of bleomycin is as follows : Each vial of BLENAMAX ® contains a lyophilised powder, consisting of 15,000 IU bleomycin sulfate, and sodium hydroxide/hydrochloric acid for pH adjustment . PHARMACOLOGY The exact mechanism of action of bleomycin is not known, but it is thought that the main action is to produce single and double strand breaks in DNA, causing inhibition of cell division and growth, and inhibition of DNA synthesis in the cells. Bleomycin is probably most effective against cells in the M and G2 (premitotic) phase of the cell cycle. It has not been shown to have an immunosuppressive effect _in _ BLENAMAX- Product Information Page 2 of 8 _vitro _and shows no significant inhibition of immune response in patients treated with the drug. The mechanism of action of bleomycin in the treatment of malignant pleural effusion is not completely known. The most likely mechanism is a local inflammatory effect resulting in fibrous adhesion as it resolves; however, a local cytotoxic effect cannot be entirely excluded. Bleomycin-inactivating enzyme has been detected in both normal and malignant cells and is particularly prominent in the liver. The enzyme is not found in lung or skin, two normal tissues, which are sensitive to bleomycin action . PHARMACOKINETICS ABSORPTION: Bleomycin is Soma hati kamili