BLENAMAX

Country: অস্ট্রেলিয়া

ভাষা: ইংরেজি

সূত্র: Department of Health (Therapeutic Goods Administration)

সক্রিয় উপাদান:

Bleomycin sulfate

থেকে পাওয়া:

Aspen Pharma Pty Ltd

শ্রেণী:

Medicine Registered

পণ্য বৈশিষ্ট্য

BLENAMAX- Product Information 

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PRODUCT INFORMATION 

BLENAMAX
®

POWDER FOR INJECTION 

NAME OF THE DRUG 

BLENAMAX
®
 (bleomycin sulfate) 15,000 IU powder for injection 

DESCRIPTION 

Bleomycin sulfate is an antineoplastic antibiotic. It is the
sulfate of a mixture of glycopeptides isolated 
from a strain of _Streptomyces verticillus _; the
two principal components of the mixture are bleomycin A2 
and B2. The CAS No. of bleomycin sulfate is 9041-34-4. The
chemical structure of bleomycin is as 
follows
: 

Each vial of BLENAMAX
® 
contains a lyophilised powder, consisting of 15,000 IU bleomycin
sulfate, and 
sodium hydroxide/hydrochloric acid for pH adjustment
. 

PHARMACOLOGY 

The exact mechanism of action of bleomycin is not known,
but it is thought that the main action is to 
produce single and double strand breaks in DNA, causing inhibition
of cell division and growth, and 
inhibition of DNA synthesis in the cells. Bleomycin
is probably most effective against cells in the M and 
G2  (premitotic) phase of the cell cycle.
It has not been shown to have an immunosuppressive
effect _in _
BLENAMAX- Product Information 

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_vitro _and shows no significant inhibition of immune response in
patients treated with the drug. The 
mechanism of action of bleomycin in the
treatment of malignant pleural effusion is
not completely known. 
The most likely mechanism is
a local inflammatory effect resulting in fibrous
adhesion as it resolves; 
however, a local cytotoxic effect cannot be entirely excluded.
Bleomycin-inactivating enzyme has been 
detected in both normal and malignant cells and is particularly

prominent

in the liver. The enzyme is not 
found in lung or skin, two normal tissues, which are sensitive
to bleomycin action
. 

PHARMACOKINETICS 

ABSORPTION: Bleomycin is�