APO-ALLOPURINOL TABLET 300MG

Nchi: Malesia

Lugha: Kiingereza

Chanzo: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Viambatanisho vya kazi:

ALLOPURINOL

Inapatikana kutoka:

PHARMAFORTE (MALAYSIA) SDN. BHD.

INN (Jina la Kimataifa):

ALLOPURINOL

Vitengo katika mfuko:

500 Tablets; 100 Tablets

Viwandani na:

APOTEX INC

Taarifa za kipeperushi

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_
_ _
APO-ALLOPURINOL TABLET
_ _
Allopurinol (100mg, 300mg)
1
WHAT IS IN THIS LEAFLET
1.
What Apo-Allopurinol is used
for
2.
How Apo-Allopurinol works
3.
Before you use Apo-Allopurinol
4.
How to use Apo-Allopurinol
5.
While you are using it
6.
Side Effects
7.
Storage and Disposal of Apo-
Allopurinol
8.
Product Description
9.
Manufacturer and Product
Registration Holder
10.
Date of Revision
WHAT APO-ALLOPURINOL IS USED FOR
It is used to treat and prevent gout.
Also indicated for treatment of kidney
injury resultant from high uric acid in
the body.
May be given to prevent uric acid
deposition in kidney due to elevating
serum
uric
acid
concentrations
resulting
from
radiation
therapy
or
drugs
to
treat
cancer
(such
as
leukemias and lymphomas).
It
can
also
be
used
to
prevent
occurrence and recurrence of uric acid
or kidney stones in individual with
elevated uric acid level in blood and
urine.
HOW APO-ALLOPURINOL WORKS
Allopurinol
works
by
blocking
an
enzyme, which is responsible for the
formation of uric acid. High uric acid
will cause gout and kidney injury.
BEFORE YOU USE APO-ALLOPURINOL
_-When you must not use it _
Do not use Apo-Allopurinol
•
if you are allergic to allopurinol
or any other ingredients of Apo-
Allopurinol.
•
in children (except in those with
hyperuricemia (high serum uric
acid ) secondary to malignancy
or genetic disorders).
•
if you are breast-feeding.
_-Before you start to use it _
Tell your doctor if:
1.
you
are
allergic
to
any
other
medicines or any other substances
_ _
2.
you
have
or
have
had
medical
condition especially the following
•
Liver problem
_ _
•
Kidney problem
_ _
•
Cancer
_ _
•
High blood pressure
_ _
•
Conditions
where
the
levels
of
uric acid are abnormally high
3. you are having an attack of gout
_Pregnancy and lactation _
_ _
Please
consult
your
doctor
or
pharmacist
if
you
are
pregnant,
planning
for
pregnancy
or
breast-
feeding before using any medicine
_-Taking other medicines _
Tell your doctor if you are taking:
�

Tabia za bidhaa

APO-ALLOPURINOL
ALLOPURINOL TABLETS USP 100MG AND 300MG
XANTHINE OXIDASE INHIBITOR
PHARMACOLOGY: Allopurinol is structural analogue of the natural purine
base, hypoxanthine. It is a potent
inhibitor of xanthine oxidase, the enzyme responsible for the
conversion of hypoxanthine to xanthine and of
xanthine to uric acid. When taken orally, allopurinol is rapidly
absorbed and rapidly metabolized. The main
metabolite is oxypurinol, which is itself a xanthine oxidase
inhibitor. Allopurinol and its metabolites are excreted
by the kidney but the renal handling is such that allopurinol has a
plasma half-life about 1 hour, whereas that of
oxypurinol exceeds 18 hours. Thus, the therapeutic effect can be
achieved by a once a day allopurinol dosage in
patients taking 300mg or less/day. Administration of allopurinol
generally results in a fall in both serum and
urinary uric acid within 2 to 3 days. The magnitude of this decrease
can be manipulated almost ad lib since it is
dose dependent to a limited extent. A week or more of treatment with
allopurinol may be required for full effects
of the drug to be manifest since the serum uric acid concentration
falls gradually; likewise uric acid may return to
pretreatment concentration slowly, usually after a period of 7 to 10
days following cessation of therapy. This
reflects primarily the slow accumulation and clearance of oxypurinol.
In some patients, particularly those with
tophaceous gout, a significant fall in urinary uric acid excretion may
not occur. It has been postulated that this
fall may be due to the mobilization of urate from the tissue deposits
as the serum uric acid concentration begins
to fall. It has been shown that reutilization of both hypoxanthine and
xanthine for nucleotide and nucleic acid
synthesis is markedly enhanced when their oxidations are inhibited by
allopurinol. This reutilization and the
normal feedback inhibition which would result from an increase in
available purine nucleotides serve to regulate
purine biosynthesis, and, in essence, the defect of the