Pays: Malaisie
Langue: anglais
Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
ALLOPURINOL
PHARMAFORTE (MALAYSIA) SDN. BHD.
ALLOPURINOL
500 Tablets; 100 Tablets
APOTEX INC
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_ _ _ APO-ALLOPURINOL TABLET _ _ Allopurinol (100mg, 300mg) 1 WHAT IS IN THIS LEAFLET 1. What Apo-Allopurinol is used for 2. How Apo-Allopurinol works 3. Before you use Apo-Allopurinol 4. How to use Apo-Allopurinol 5. While you are using it 6. Side Effects 7. Storage and Disposal of Apo- Allopurinol 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of Revision WHAT APO-ALLOPURINOL IS USED FOR It is used to treat and prevent gout. Also indicated for treatment of kidney injury resultant from high uric acid in the body. May be given to prevent uric acid deposition in kidney due to elevating serum uric acid concentrations resulting from radiation therapy or drugs to treat cancer (such as leukemias and lymphomas). It can also be used to prevent occurrence and recurrence of uric acid or kidney stones in individual with elevated uric acid level in blood and urine. HOW APO-ALLOPURINOL WORKS Allopurinol works by blocking an enzyme, which is responsible for the formation of uric acid. High uric acid will cause gout and kidney injury. BEFORE YOU USE APO-ALLOPURINOL _-When you must not use it _ Do not use Apo-Allopurinol • if you are allergic to allopurinol or any other ingredients of Apo- Allopurinol. • in children (except in those with hyperuricemia (high serum uric acid ) secondary to malignancy or genetic disorders). • if you are breast-feeding. _-Before you start to use it _ Tell your doctor if: 1. you are allergic to any other medicines or any other substances _ _ 2. you have or have had medical condition especially the following • Liver problem _ _ • Kidney problem _ _ • Cancer _ _ • High blood pressure _ _ • Conditions where the levels of uric acid are abnormally high 3. you are having an attack of gout _Pregnancy and lactation _ _ _ Please consult your doctor or pharmacist if you are pregnant, planning for pregnancy or breast- feeding before using any medicine _-Taking other medicines _ Tell your doctor if you are taking: Lire le document complet
APO-ALLOPURINOL ALLOPURINOL TABLETS USP 100MG AND 300MG XANTHINE OXIDASE INHIBITOR PHARMACOLOGY: Allopurinol is structural analogue of the natural purine base, hypoxanthine. It is a potent inhibitor of xanthine oxidase, the enzyme responsible for the conversion of hypoxanthine to xanthine and of xanthine to uric acid. When taken orally, allopurinol is rapidly absorbed and rapidly metabolized. The main metabolite is oxypurinol, which is itself a xanthine oxidase inhibitor. Allopurinol and its metabolites are excreted by the kidney but the renal handling is such that allopurinol has a plasma half-life about 1 hour, whereas that of oxypurinol exceeds 18 hours. Thus, the therapeutic effect can be achieved by a once a day allopurinol dosage in patients taking 300mg or less/day. Administration of allopurinol generally results in a fall in both serum and urinary uric acid within 2 to 3 days. The magnitude of this decrease can be manipulated almost ad lib since it is dose dependent to a limited extent. A week or more of treatment with allopurinol may be required for full effects of the drug to be manifest since the serum uric acid concentration falls gradually; likewise uric acid may return to pretreatment concentration slowly, usually after a period of 7 to 10 days following cessation of therapy. This reflects primarily the slow accumulation and clearance of oxypurinol. In some patients, particularly those with tophaceous gout, a significant fall in urinary uric acid excretion may not occur. It has been postulated that this fall may be due to the mobilization of urate from the tissue deposits as the serum uric acid concentration begins to fall. It has been shown that reutilization of both hypoxanthine and xanthine for nucleotide and nucleic acid synthesis is markedly enhanced when their oxidations are inhibited by allopurinol. This reutilization and the normal feedback inhibition which would result from an increase in available purine nucleotides serve to regulate purine biosynthesis, and, in essence, the defect of the Lire le document complet