YH Bacitracin Zinc 15% WW Granule

Land: Malaysia

Språk: engelska

Källa: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Aktiva substanser:

BACITRACIN ZINC

Tillgänglig från:

Yenher Agro-products Sdn. Bhd.

INN (International namn):

BACITRACIN ZINC

Enheter i paketet:

25 kg

Tillverkad av:

Lifecome Biochemistry Co. Ltd.

Produktens egenskaper

YH BACITRACIN ZINC 15%W/W GRANULE
ACTIVE CONSTITUENT:
Bacitracin Zinc 750 mg/g (As bacitracin 150mg). 1mg bacitracin
equivalent
to 42iu.
PRODUCT DESCRIPTION:
Light brown or tan granule.
ROUTE OF ADMINISTRATION:
Oral administration.
INDICATIONS:
For the treatment of Necrotic Enteritis (
_Clostridium perfringens_
Types A and C) and as an aid in the
prevention of Necrotic Enteritis in poultry.
RECOMMENDED DOSAGE:
Should be premixed with 10-20 kg of feed and then thoroughly mixed
with the bulk feed.
Aid in the prevention of Necrotic Enteritis: Add YH Bacitracin Zinc
15% W/W Granule at the rate of 267
g/tonne of finished feed (corresponding to 40g bacitracin activity per
tonne).
Treatment of Necrotic Enteritis: Add YH Bacitracin Zinc 15% W/W
Granule at the rate of 1.33kg/tonne of
finished feed (corresponding to 200g bacitracin activity per tonne) to
be fed for 5-7 days.
PHARMACODYNAMICS &PHARMACOKINETIC:
Bacitracin is an antibiotic from the group of peptide antibacterial
compounds. Bacitracin is produced by
_Bacillus lincheniformis_
, and is a mixture of several closely related polypeptides, mainly
consisting of
bacitracin A, B1, B2, C and a small portion of bacitracin F.
Bacitracin is mainly active against gram-
positive microorganisms. Bacitracin inhibits cell wall biosynthesis by
inhibiting lipid pyrophosphatase
which is involved in transmembrane transport of peptidoglycan
precursors. After oral application to
chickens and pigs, bacitracin is hardly absorbed from the
gastrointestinal tract, and the distribution to
organs and tissues is negligible. In chickens and pigs, approximately
95% of an oral dose is excreted via
faeces, and only 3% or less via urine. Bacitracin is metabolized to
amino acids and smaller peptides via the
main metabolite desamido-bacitracin, which is microbiologically
inactive.
WARNINGS AND PRECAUTIONS:
Any variation by prescribing veterinarian to the approved dose,
frequency, duration, route, disease or target
species may require extending the approved withholding period.
INTERACTION WITH OTHER