Timoptol

Land: Australien

Språk: engelska

Källa: Department of Health (Therapeutic Goods Administration)

Aktiva substanser:

Timolol maleate

Tillgänglig från:

Merck Sharp & Dohme Australia Pty Ltd

Klass:

Medicine Listed (Export Only)

Bipacksedel

TIMOPTOL
®

_Timolol maleate_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about TIMOPTOL. It does
not contain all the available
information.
It does not take the place of talking to
your doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you using TIMOPTOL
against the benefits they expect it
will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
USING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT TIMOPTOL IS
USED FOR
TIMOPTOL is used to lower raised
pressure in the eye and to treat
glaucoma. Glaucoma is a condition
in which the pressure of fluid in the
eye may be high. However, some
people with glaucoma may have
normal eye pressure. Also, some
people with raised eye pressure may
not have glaucoma.
Glaucoma is usually caused by a
build-up of the fluid which flows
through the eye. This build up occurs
because the fluid drains out of your
eye more slowly than it is being
pumped in. Since new fluid continues
to enter the eye, joining the fluid
already there, the pressure continues
to rise. This raised pressure may
damage the back of the eye resulting
in gradual loss of sight. Damage can
progress so slowly that the person is
not aware of this gradual loss of
sight. Sometimes even normal eye
pressure is associated with damage to
the back of the eye.
There are usually no symptoms of
glaucoma. The only way of knowing
that you have glaucoma is to have
your eye pressure, optic nerve and
visual field checked by an eye
specialist or optometrist. If glaucoma
is not treated it can lead to serious
problems. You may have no
symptoms but eventually glaucoma
can lead to total blindness. In fact,
untreated glaucoma is one of the
most common causes of blindness.
Although TIMOPTOL helps control
your glaucoma it does not cure it.
For more information about
glaucoma, contact Glaucoma
Australia Inc., PO Box 420, Crows
Nest 1585, telephone [phone].
TIM

Produktens egenskaper

IPC- MK0950-OS-092012                                

1 
PRODUCT INFORMATION 

STERILE Ophthalmic Solution 
0.25% and 0.5% 

Trademark 
TIMOPTOL
®

(timolol maleate) 

DESCRIPTION 

Timolol  maleate  is  a  beta-adrenergic  receptor  blocking  agent.  Its  chemical  name  is  (S)-1-
((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl) -1,2,5-thiadiazol-3-yl)oxy)-2-propanol, 
(Z)-butenedioate(1:1)salt.  Timolol  maleate  possesses  an  asymmetric  carbon  atom  in  its 
structure and is provided as the levo
isomer. It has the following structural formula: 

PHARMACOLOGY 

Timolol  maleate  is  a  non-selective  beta-adrenergic  receptor  blocking  agent  that  does  not 
have  significant  intrinsic  sympathomimetic,  direct  myocardial  depressant,  or  local 
anaesthetic (membrane-stabilising) activity. Timolol maleate combines reversibly with a part 
of  the  cell  membrane,  the  beta-adrenergic  receptor,  and  thus  inhibits  the  usual  biological 
response  that  would  occur  with  stimulation  of  that  receptor.  This  specific  competitive 
antagonism  blocks  stimulation  of  the  beta-adrenergic  receptors  by  catecholamines  having 
beta-adrenergic  stimulating  (agonist)  activity,  whether  these  originate  from  an  endogenous 
or  exogenous  source.  Reversal  of  this  blockade  can  be  accomplished  by  increasing  the 
concentration of the agonist, which will restore
the usual biological response. 

Ophthalmic Solution TIMOPTOL (timolol maleate)  reduces elevated and normal intraocular 
pressure whether or not associated with glaucoma. Elevated intraocular pressure is a major 
risk  factor  in  the  pathogenesis  of  glaucomatous  visual  loss.  The�