THIAMINE hydrochloride injection solution

Land: USA

Språk: engelska

Källa: NLM (National Library of Medicine)

Aktiva substanser:

THIAMINE HYDROCHLORIDE (UNII: M572600E5P) (THIAMINE ION - UNII:4ABT0J945J)

Tillgänglig från:

Cardinal Health

INN (International namn):

THIAMINE HYDROCHLORIDE

Sammansättning:

THIAMINE HYDROCHLORIDE 100 mg in 1 mL

Receptbelagda typ:

PRESCRIPTION DRUG

Bemyndigande status:

Abbreviated New Drug Application

Produktens egenskaper

THIAMINE- THIAMINE HYDROCHLORIDE INJECTION, SOLUTION
CARDINAL HEALTH
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THIAMINE HYDROCHLORIDE INJECTION, USP
DESCRIPTION:
Thiamine Hydrochloride Injection, USP is a sterile solution of
thiamine hydrochloride in Water for
Injection for intramuscular (IM) or slow intravenous (IV)
administration.
Each mL contains: Thiamine hydrochloride 100 mg; chlorobutanol
anhydrous (chloral derivative) 0.5%;
monothioglycerol 0.5%; water for injection q.s. Sodium hydroxide may
have been added for pH
adjustment (2.5 to 4.5).
Thiamine hydrochloride, or vitamin B , occurs as white crystals or
crystalline powder that usually has a
slight characteristic odor. Freely soluble in water; soluble in
glycerin; slightly soluble in alcohol;
insoluble in ether and benzene. Thiamine is rapidly destroyed in
neutral or alkaline solutions but is
stable in the dry state. It is reasonably stable to heat in acid
solution.
The chemical name of thiamine hydrochloride is
thiazolium,3-[(4-amino-2-methyl-5-
pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylchloride,
monohydrochloride and it has the following
structural formula:
C H CIN OS • HCL M.W. 337.27
CLINICAL PHARMACOLOGY:
The water soluble vitamins are widely distributed in both plants and
animals. They are absorbed in man
by both diffusion and active transport mechanisms. These vitamins are
structurally diverse (derivatives
of sugar, pyridine, purines, pyrimidine, organic acid complexes and
nucleotide complex) and act as
coenzymes, as oxidation-reduction agents, possibly as mitochondrial
agents. Metabolism is rapid, and
the excess is excreted in the urine.
Thiamine is distributed in all tissues. The highest concentrations
occur in liver, brain, kidney and heart.
When thiamine intake is greatly in excess of need, tissue stores
increase two to three times. If intake is
insufficient, tissues become depleted of their vitamin content.
Absorption of thiamine following IM
administration is rapid and complete.
Thiamine combines with adenosine triphosphate (ATP) to form thiamine
pyrophosphate, also