SELGENE selegiline hydrochloride 5mg tablet bottle

Land: Australien

Språk: engelska

Källa: Department of Health (Therapeutic Goods Administration)

Aktiva substanser:

selegiline hydrochloride

Tillgänglig från:

Alphapharm Pty Ltd

Bemyndigande status:

Registered

Bipacksedel

SELGENE
_contains the active ingredient selegiline hydrochloride_
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Selgene.
It does not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have benefits and
risks. Your doctor has weighed the
risks of you taking Selgene against
the benefits expected for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, TALK TO YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH YOUR
MEDICINE.
You may need to read it again.
WHAT SELGENE IS USED
FOR
Selgene is used to treat some of the
symptoms of Parkinson's disease.
It can be used alone or taken in
combination with levodopa (another
medicine used for Parkinson's
disease). When taken together with
levodopa, Selgene can help reduce
the need for high levodopa doses.
Parkinson's disease is a condition that
mainly affects body movement. The
three main symptoms of Parkinson's
disease are:
•
shaking (tremor)
•
muscle stiffness
•
slow and unsteady movement.
These symptoms are caused by a lack
of dopamine, a naturally occurring
substance produced by certain brain
cells.
Selgene belongs to a group of
medicines called monoamine oxidase
B inhibitors. It increases the amount
of dopamine in the brain.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY SELGENE HAS
BEEN PRESCRIBED FOR YOU.
Your doctor may have prescribed
Selgene for another reason.
Selgene is available only with a
doctor's prescription.
Selgene is not recommended for use
in children, as its safety and
effectiveness have not been
established in this age group.
BEFORE YOU TAKE
SELGENE
_WHEN YOU MUST NOT TAKE IT_
DO NOT TAKE SELGENE IF YOU ARE
ALLERGIC TO MEDICINES CONTAINING
SELEGILINE HYDROCHLORIDE (E.G.
ELDEPRYL) OR ANY OF THE INGREDIENTS
LISTED AT THE END OF THIS LEAFLET.
DO NOT TAKE SELGENE IF YOUR DOCTOR
HAS ALREADY TOLD YOU TO STOP TAKING
LEVODOPA.
Some medicines containing levodopa
include Sinemet, Kinson and
Madopar.
DO NOT TAKE SELGENE IF Y

Produktens egenskaper

SELGENE
_Selegiline hydrochloride _
PRODUCT INFORMATION
NAME OF THE MEDICINE
Active ingredient
:
Selegiline hydrochloride
Chemical name
:
(R)-methyl(

-methylphenethyl)-prop-2-ynylamine hydrochloride
Structural formula
:
Molecular formula
:
C
13
H
17
N,HCl
Molecular weight
:
223.75
CAS Registry no.
:
14611-52-0 DESCRIPTION
Selegiline hydrochloride is a white to near white crystalline powder,
freely soluble in water, chloroform and
methanol. Each Selgene tablet contains 5 mg of selegiline
hydrochloride. The tablets also contain lactose,
maize starch, citric acid monohydrate, povidone, purified talc and
magnesium stearate.
PHARMACOLOGY
PHARMACODYNAMICS
Selegiline is an irreversible inhibitor of MAO, an intracellular
enzyme associated with the outer membrane of
mitochondria. Selegiline acts as a "suicide" substrate for MAO, i.e.
it is converted by MAO to an active moiety
which combines irreversibly with the active site of the enzyme and/or
the enzyme's essential flavine adenine
dinucleotide (FAD) cofactor. MAOs are currently subclassified into two
types, A and B. MAO type A (MAO-
A) and MAO type B (MAO-B) differ in their substrate specificity and
tissue distribution. In humans most of the
MAO in the brain is type B, while intestinal MAO is predominantly type
A. At the recommended dose,
selegiline's affinity for type B active sites is greater than for type
A, and it serves as a selective inhibitor of
MAO-B. However, this selectivity is dose dependent and at higher than
recommended doses (>20 mg/day), it
may be lost, resulting in increased inhibition of MAO-A. The precise
dose at which selegiline becomes a
nonselective inhibitor of all MAO is unknown.
The rate of MAO-B regeneration following discontinuation of selegiline
treatment is dependent upon _de novo_
protein synthesis. This rate, which has not been quantified, seems
likely to determine how fast normal MAO-B
activity can be restored. MAO plays an important role in the
catabolism of catecholamines (dopamine,
noradrenaline and adrenaline) and serotonin in CNS