Land: Malaysia
Språk: engelska
Källa: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
LOSARTAN POTASSIUM
HEALOL PHARMACEUTICALS SDN. BHD.
LOSARTAN POTASSIUM
30 Tablets; 100 Tablets; 30 Tablets; 100 Tablets
Aurobindo Pharma Limited (Unit III),
SARANTO _Consumer Medication Information Leaflet (RiMUP)_ Losartan Potassium Tablet (50 mg, 100 mg) 1 WHAT IS IN THIS LEAFLET 1. What Saranto is used for 2. How Saranto works 3. Before you use Saranto 4. How to use Saranto 5. While you are using it 6. Side effects 7. Storage and Disposal of Saranto 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of revision 11. Serial number WHAT IS SARANTO USED FOR Hypertension (High Blood Pressure) Hypertensive Patients with Left Ventricular Hypertrophy (Enlargement of Left Ventricle of the Heart). Losartan Potassium is indicated to reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. Nephropathy (Appearance of Low but abnormal levels of albumin in the urine) in Type 2 Diabetic Patients Losartan Potassium may also be used to treat other conditions, for example, heart failure and kidney disease in diabetic patients with high blood pressure. HOW SARANTO WORKS Saranto belongs to a group of medicines known as angiotensin-II receptor antagonists. Angiotensin- II is a substance produced in the body which binds to receptors in blood vessels, causing them to tighten. This results in an increase in blood pressure. Saranto prevents the binding of angiotensin-II to these receptors, causing the blood vessels to relax which in turn lowers the blood pressure. Saranto slows the decrease of kidney function in patients with high blood pressure and type 2 diabetes. BEFORE YOU USE SARANTO _-When you must not use it _ You are allergic (hypersensitive) to losartan or any of its other ingredients, You are more than 3 months pregnant. (It is also better to avoid Saranto in early pregnancy) _-Before you start to use it _ It is important to tell your doctor before taking Saranto if :- You have a history of angioedema (swelling of the face, lips, throat, mouth and/or tongue) as you may be more likely to develop an allergic reaction. You think you are (or might become) pregnant. Saranto is not recommended in Läs hela dokumentet
Additional Information : TEAM LEADER Lova Raju INITIATOR Bharath Saranto 50 PRODUCT NAME CUSTOMER / COUNTRY Malaysia DIMENSIONS 110 x 230 mm PHARMACODE 14417 COMPONENT 04 Leaflet VERSION NO. REASON OF ISSUE Revision P1514417 ITEM CODE REVIEWED / APPROVED BY DATE & TIME 05.06.2018 & 5:25 PM SIGN / DATE Artist: NO. OF COLOURS : 01 Supersede item Code: P1510049 WOS-17-000125 NAME OF THE PRODUCT: SARANTO 50 (Losartan Potassium Tablets 50 mg) NAME AND STRENGTH OF ACTIVE INGREDIENT : Losartan Potassium Ph.Eur. and 50 mg. DOSAGE FORM: Tablet. PRODUCT DESCRIPTION: White to off-white, oval shaped, biconvex film- coated tablets debossed with 'E' on one side and '4' and '6' separated by a scoreline on other side. PHARMACODYNAMICS/PHARMACOKINETICS PHARMACODYNAMICS: Losartan is an oral, specific angiotensin-II receptor (type AT1) antagonist. Angiotensin II binds to the AT1 receptor found in many tissues (e.g. vascular smooth muscle, adrenal gland, kidneys, and the heart) and elicits several important biological actions, including vasoconstriction and the release of aldosterone. Angiotensin II also stimulates smooth-muscle proliferation. Based on binding and pharmacological bioassays, it binds selectively to the AT1 receptor. During Losartan administration, removal of angiotensin-II negative feedback on renin secretion leads to increased plasma renin activity. Increases in plasma renin activity lead to increases in angiotensin II in plasma. Even with these increases, antihypertensive activity and suppression of plasma aldosterone concentration are maintained, indicating effective angiotensin-II receptor blockade. Losartan binds selectively to the AT1 receptor and does not bind to or block other hormone receptors or ion channels important in cardiovascular regulation. Furthermore, Losartan does not inhibit ACE (kininase II), the enzyme that degrades bradykinin. Losartan block responses to angiotensin I and angiotensin II without affecting responses to bradykinin. In non-diabetic hypertensive patients with proteinuria, the admin Läs hela dokumentet