Land: Australien
Språk: engelska
Källa: Department of Health (Therapeutic Goods Administration)
Cyclosporin
Novartis Pharmaceuticals Australia Pty Ltd
Medicine Registered
SANDIMMUN ® _cyclosporin_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Sandimmun. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. The information in this leaflet was last updated on the date listed on the final page. More recent information on the medicine may be available. YOU SHOULD ENSURE THAT YOU SPEAK TO YOUR PHARMACIST OR DOCTOR TO OBTAIN THE MOST UP TO DATE INFORMATION ON THE MEDICINE. YOU CAN ALSO DOWNLOAD THE MOST UP TO DATE LEAFLET FROM WWW.NOVARTIS.COM.AU. Those updates may contain important information about the medicine and its use of which you should be aware. All medicines have risks and benefits. Your doctor has weighed the risks of you taking Sandimmun against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again. WHAT SANDIMMUN IS USED FOR Sandimmun is used for people who have had a kidney, heart or liver transplant, to prevent the body from rejecting the new organ. It does this by blocking the development of special cells which would normally attack the transplanted tissue. Sandimmun is also used to treat several other conditions which are thought to be caused by a problem with the immune system: • a kidney disease, called nephrotic syndrome • severe cases of rheumatoid arthritis (a disease, affecting the joints with pain and swelling) • severe cases of : - psoriasis (a skin disease with thickened patches of red skin, often with silvery scales) - atopic dermatitis (skin allergies) Sandimmun contains the active ingredient, cyclosporin. It belongs to a group of medicines called immuno- suppressive agents. These medicines help to control your body's immune system. ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY THIS MEDICINE HAS BEEN PRESCRIBED FOR YOU. Your doctor may have prescribed it for another rea Läs hela dokumentet
1 SANDIMMUN ® (CYCLOSPORIN) Immunosuppressive agent DESCRIPTION Cyclosporin (BAN, AAN), ciclosporin (prop. INN), cyclosporine (USAN), also known as Cyclosporin A. A cyclic polypeptide consisting of 11 amino acids. It is produced as a metabolite by the fungus species _Beauveria nivea_ (formerly _Tolypocladium inflatum Gams_). Chemical Name: Cyclo[[(2_S_,3_R_,4_R_,6_E_)-3-hydroxy-4-methyl-2-(methylamino)oct-6- enoyl]-_L_-2-aminobutanoyl-_N_-methylglycyl-_N_-methyl-_L_-leucyl-_L_-valyl- _N_-methyl-l-leucyl-_L_-alanyl-_D_-alanyl-_N_-methyl-_L_-leucyl-_N_-methyl-_L_- leucyl-_N_-methyl-_L_-valyl] Chemical formula: C 62 H 111 N 11 O 12 Chemical structure: N CH CO N CH C N CH CO N CH C N CH 2 CH CH N CO CH OC N CO CO CH N O H N C CH N O H O H CO CH CO N CH 2 CH CH 3 CH 3 CH 3 CH CH 3 CH 3 CH 3 CH CH CH 3 HO CH 2 C H C H CH 3 CH 2 CH 3 CH 3 CH 2 CH CH 3 CH 3 CH CH 3 CH 3 CH 3 CH 2 CH CH 3 CH 3 CH 3 H CH 3 CH 2 CH CH 3 CH 3 CH 3 CH 3 CH 3 L L L L L L L L L D (R) (R) Molecular Weight: 1202.635 CAS Number: 59865-13-3 Cyclosporin is poorly soluble in water (0.004% w/w) and n-hexane, but is very soluble in other organic solvents and in lipids. EXCIPIENTS Sandimmun capsules and oral solution contain maize oil, ethanol (see PRECAUTIONS), and inter-esterified maize oil. Sandimmun soft gelatin capsule shells contain gelatin, glycerol, titanium dioxide, iron oxide red CI77491 (25 and 100 mg capsules only), iron oxide yellow CI 77492 (50 mg capsules), and Anidrisorb 85/70 (sorbitol syrup). Sandimmun concentrate for intravenous infusion contains castor oil – polyoxyethylated, macrogolglycerol ricinoleate (Cremophor ® EL) 65 %, and ethanol 26 % w/v (see PRECAUTIONS). 2 PHARMACOLOGY PHARMACODYNAMIC PROPERTIES Pharmacotherapeutic group: immunosuppressive agents, calcineurin inhibitors Läs hela dokumentet