Land: Armenien
Språk: engelska
Källa: Դեղերի և բժշկական տեխնոլոգիաների փորձագիտական կենտրոնի գործունեության Հայաստանի Հանրապետությունում
permethrin
Arpimed LLC
permethrin
50mg/g
cream
OTC
SUMMARY PRODUCT CHARACTERISTIC (SPC) PERMETHRIN 5% CREAM FOR TOPICAL USE TRADE NAME – Permethrin INTERNATIONAL NON-PROPERTY NAME - Permethrin PHARMACEUTICAL FORM - cream for topical use COMPOSITION Each gram contains: _ACTIVE INGREDIENT: _permethrin – 50 mg; _INACTIVE INGREDIENTS:_ ceteareth-12, ceteareth-20, cetostearyl alcohol, liquid paraffin, propylene glycol, dimethicone, methylparaben, propylparaben, glycerol monostearate, water purified. PHARMACOLOGICAL GROUP AND ATC CODE Pediculicide; ATC CODE - P03AC04. PHARMACOLOGICAL ACTION Following absorption through the chitinous exoskeleton of arthropods, permethrin stimulates the nervous system, apparently by competitively interfering with cationic conductances in the lipid layer of nerve cells, thereby blocking nerve impulse transmissions. Paralysis and death follow. SPECTRUM AND RESISTANCE Permethrin is toxic to the parasitic arthropods _Pediculus capitis _(head louse), _Pediculus corporis _(body louse), and _Phthirus pubis _(crab louse), and possibly their nits. Resistance to permethrin may develop rarely in strains of _ Pediculus corporis. _ Some lice resistant to chlorophenothane (DDT) have been reported to be cross-resistant to permethrin. Permethrin is also toxic to house-flies, fleas, chiggers, and mosquitoes. PHARMACOKINETICS _ABSORPTION _ Permethrin is absorbed through intact skin when applied topically. _DISTRIBUTION AND ELIMINATION _ The highest levels of excretion are detectable within 48 hours but very low levels of metabolite are still detectable in the urine of some individuals 28 days after treatment. The overall pattern of excretion indicates a mean of approximately 0.5% of applied permethrin is absorbed during the first 48 hours. In animals, Permethrin are rapidly metabolized to water soluble, inactive compounds. PERMETHRIN IS REPORTEDLY INACTIVATED IN THE GI TRACT FOLLOWING: INGESTION. USES -Scab (infection caused by Sarcoptes Scabiei ). -Pediculosis pubis. ADMINISTRATION The preparation is intended for topical use. The drug is carefully ru Läs hela dokumentet