Land: Sydafrika
Språk: engelska
Källa: South African Health Products Regulatory Authority (SAHPRA)
Gulf
INDICATIONS [/za_1179.html#1] [/za_1179.html#1] [/za_1179.html#1] CONTRA-INDICATIONS [/za_1179.html#1] [/za_1179.html#1] DOSAGE [/za_1179.html#1] [/za_1179.html#1] SIDE-EFFECTS [/za_1179.html#1] [/za_1179.html#1] [/za_1179.html#1] PREGNANCY [/za_1179.html#1] [/za_1179.html#1] OVERDOSE [/za_1179.html#1] IDENTIFICATION [/za_1179.html#1] [/za_1179.html#1] PATIENT INFORMATION GULF AMLODIPINE 5 (TABLETS) GULF AMLODIPINE 10 (TABLETS) SCHEDULING STATUS: S3 PROPRIETARY NAME (and dosage form): GULF AMLODIPINE 5 (TABLETS) GULF AMLODIPINE 10 (TABLETS) COMPOSITION: GULF AMLODIPINE 5: Each tablet contains Amlodipine Besilate equivalent to 5 mg AMLODIPINE GULF AMLODIPINE 10: Each tablet contains Amlodipine Besilate equivalent to 10 mg Amlodipine PHARMACOLOGICAL CLASSIFICATION: A 7.1Vasodilators, hypotensive medicines PHARMACOLOGICAL ACTION: Amlodipine is a dihydropyridine calcium channel blocker. It inhibits the transmembrane influx of calcium ions into cardiac and vascular smooth muscle without affecting serum calcium concentrations. Direct relaxation of vascular smooth muscle forms the basis of the antihypertensive action. In angina pectoris, Amlodipine acts as a peripheral arteriolar vasodilator resulting in a reduction in total peripheral resistance (afterload). Myocardial energy and oxygen requirements are reduced. Amlodipine exerts its activity by binding to the dihydropyridine binding sites. It exerts minimal action on cardiac conduction, contraction and heart rate. PHARMACOKINETICS: Complete absorption of Amlodipine is slow following oral administration with peak plasma levels being attained after 6 to 12 hours. Amlodipine has a bioavailability of about 64% and plasma elimination half –life of 35 to 50 hours, allowing for once-daily oral dosing. Steady state plasma Läs hela dokumentet