DIBETASOL INJECTION

Land: Malaysia

Språk: engelska

Källa: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Aktiva substanser:

BETAMETHASONE SODIUM PHOSPHATE; BETAMETHASONE DIPROPIONATE

Tillgänglig från:

THE ZYFAS MEDICAL CO.,

INN (International namn):

BETAMETHASONE SODIUM PHOSPHATE; BETAMETHASONE DIPROPIONATE

Enheter i paketet:

10Pieces Pieces

Tillverkad av:

SHIN POONG PHARM CO LTD

Produktens egenskaper

DIBETASOL Injection provides a combination of highly soluble and very
slightly soluble esters of beta-
methasone that produce marked prompt, and sustained anti-inflammatory,
anti-rheumatic, and anti
allergic effects.
Prompt therapeutic activity in corticosteroid-responsive condition is
achieved by the soluble eater, beta-
methasone sodium phosphate, which is quickly absorbed after injection
Sustained activity is provided by betamathasone dipropionate, which is
only slightly soluble and affords
a repository for slow absorption, thereby controlling symptoms over a
prolonged period.
DESCRIPTION
DIBETASOL Injection is a white suspension in a colorless clear glass
vial. It comes in a box of 10 vials.
■
COMPOSITION : Each vial(1mL) contains
Betamethasone
dipropionate……………………………………………………………………………………6.43mg
Betamethasone sodium
phosphate……………………………………………………………………………
2.63mg
Benzyl
alcohol……………………………………………………………………………………………………………9mg
Propylparaben…………………………………………………………………………………………………………0.2mg
Methylparaben
………………………………………………………………………………………………………
1.3mg
PHARMACOLOGY
The most of action of betamethasone disodium phosphate, a steroidal
anti – inflammatory drug on the
metabolism of collagen and non- collagen protein in rat carrageen
granuloma was studied. The inhibi-
tory effect of the steroid on the incorporation of [
3
H] proline into collagen and non-collagen protein
was progressively increased with an increase in dose and reached a
maximum at a level of 0.2mg/rat.
The effect of the steroid on the degradation of collagen and
non-collagen protein labeled with [
3
H]
proline was investigated. Betamethasone disodium phosphate inhibited
the degradation of collagen
in vivo a